The use of intra-operative tranexamic acid in shoulder surgery: Protocol for a systematic review and meta-analysis

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-01-01 DOI:10.1016/j.isjp.2020.06.003

Alexander W. Hartland , Kar H. Teoh , Mustafa S. Rashid

{"title":"The use of intra-operative tranexamic acid in shoulder surgery: Protocol for a systematic review and meta-analysis","authors":"Alexander W. Hartland , Kar H. Teoh , Mustafa S. Rashid","doi":"10.1016/j.isjp.2020.06.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Introduction</h3><p>Blood loss is an important consideration in all types of shoulder surgery. Excessive bleeding is associated with increased morbidity. Tranexamic acid (TXA) is an antifibrinolytic agent. It has been demonstrated to be effective in reducing blood loss across multiple surgical specialties. The aim of this systematic review and meta-analysis is to review the literature evaluating clinical outcomes associated with the use of TXA in shoulder surgery.</p></div><div><h3>Methods</h3><p>The study protocol was designed and registered prospectively on PROSPERO (International prospective register for systematic reviews). Literature search will include the MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases. Randomised controlled trials (RCTs) evaluating the use of TXA against placebo, in all types of shoulder surgery, will be included. Our primary outcome is total blood loss (ml). Secondary outcomes include patient-reported outcome measures (PROMs), adverse events, and number of blood transfusions required. Risk of bias will be assessed within each study using The Cochrane Risk of Bias Tool 2.0 and the Jadad score. Inconsistency and bias across included studies will be assessed statistically. Data from comparable outcomes will be pooled and analysed quantitatively or descriptively as appropriate.</p></div><div><h3>Ethics and dissemination</h3><p>No ethical clearances required for this study. This systematic review and meta-analysis will be published in a peer-reviewed journal. It will be presented a various national and international conferences.</p></div>","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.isjp.2020.06.003","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468357420300206","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction

Blood loss is an important consideration in all types of shoulder surgery. Excessive bleeding is associated with increased morbidity. Tranexamic acid (TXA) is an antifibrinolytic agent. It has been demonstrated to be effective in reducing blood loss across multiple surgical specialties. The aim of this systematic review and meta-analysis is to review the literature evaluating clinical outcomes associated with the use of TXA in shoulder surgery.

Methods

The study protocol was designed and registered prospectively on PROSPERO (International prospective register for systematic reviews). Literature search will include the MEDLINE, EMBASE, PsycINFO, and Cochrane Library databases. Randomised controlled trials (RCTs) evaluating the use of TXA against placebo, in all types of shoulder surgery, will be included. Our primary outcome is total blood loss (ml). Secondary outcomes include patient-reported outcome measures (PROMs), adverse events, and number of blood transfusions required. Risk of bias will be assessed within each study using The Cochrane Risk of Bias Tool 2.0 and the Jadad score. Inconsistency and bias across included studies will be assessed statistically. Data from comparable outcomes will be pooled and analysed quantitatively or descriptively as appropriate.

Ethics and dissemination

No ethical clearances required for this study. This systematic review and meta-analysis will be published in a peer-reviewed journal. It will be presented a various national and international conferences.

查看原文本刊更多论文

肩关节手术中术中氨甲环酸的使用:系统回顾和荟萃分析方案

在所有类型的肩部手术中，失血都是一个重要的考虑因素。出血过多与发病率增加有关。氨甲环酸是一种抗纤溶剂。它已被证明是有效的减少失血在多个外科专业。本系统综述和荟萃分析的目的是回顾评估与肩关节手术中使用TXA相关的临床结果的文献。方法设计研究方案，并在PROSPERO (International prospective register for systematic reviews)上前瞻性注册。文献检索将包括MEDLINE、EMBASE、PsycINFO和Cochrane图书馆数据库。将包括评估在所有类型的肩部手术中使用TXA与安慰剂的随机对照试验(rct)。我们的主要终点是总失血量(ml)。次要结局包括患者报告的结局指标(PROMs)、不良事件和所需输血次数。将使用Cochrane Risk of bias Tool 2.0和Jadad评分评估每项研究的偏倚风险。纳入研究的不一致性和偏倚将进行统计学评估。可比较结果的数据将进行汇总，并酌情进行定量或描述性分析。伦理与传播本研究不需要伦理许可。该系统综述和荟萃分析将发表在同行评议的期刊上。它将在各种国内和国际会议上展出。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.