Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Hypertension in Pregnancy Pub Date : 2020-11-01 Epub Date: 2020-07-10 DOI:10.1080/10641955.2020.1793999

Mark W Cunningham, Aswathi Jayaram, Evangeline Deer, Lorena M Amaral, Venkata Ramana Vaka, Tarek Ibrahim, Denise C Cornelius, Babbette LaMarca

引用次数: 16

Abstract

The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS). Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats.

Methods: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19.

Results: MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN.

Conclusion: TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.

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肿瘤坏死因子α (TNF-α)阻断改善自然杀伤细胞(NK)活化、高血压和线粒体氧化应激在子痫前期临床前大鼠模型。

RUPP大鼠子痫前期模型显示高血压(MAP)、细胞溶解性自然杀伤(cNK)细胞、肿瘤坏死因子α (TNF-α)和线粒体活性氧(mt ROS)。目的:依那西普阻断TNF-α是否能降低RUPP大鼠的cNK细胞和mt ROS。方法:于妊娠第14天行RUPP手术，第18天给予ETAN (0.4 mg/kg)，第19天采集MAP、血液和组织。结果:与NP相比，RUPP组MAP、细胞溶解性NK细胞和mt ROS升高，并与ETAN归一化。结论:TNF-α阻断可降低胎盘缺血的血压，改善炎症反应和器官功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Hypertension in Pregnancy 医学-妇产科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6 months

期刊介绍： Hypertension in Pregnancy is a refereed journal in the English language which publishes data pertaining to human and animal hypertension during gestation. Contributions concerning physiology of circulatory control, pathophysiology, methodology, therapy or any other material relevant to the relationship between elevated blood pressure and pregnancy are acceptable. Published material includes original articles, clinical trials, solicited and unsolicited reviews, editorials, letters, and other material deemed pertinent by the editors.