Inactivation in the potassium channel KcsA

IF 3.5 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Yunyao Xu, Ann E. McDermott
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引用次数: 13

Abstract

Inactivation, the slow cessation of transmission after activation, is a general feature of potassium channels. It is essential for their function, and malfunctions in inactivation leads to numerous pathologies. The detailed mechanism for the C-type inactivation, distinct from the N-type inactivation, remains an active area of investigation. Crystallography, computational simulations, and NMR have greatly enriched our understanding of the process. Here we review the major hypotheses regarding C-type inactivation, particularly focusing on the key role played by NMR studies of the prokaryotic potassium channel KcsA, which serves as a good model for voltage gated mammalian channels.

Abstract Image

钾离子通道KcsA失活
失活,即激活后缓慢停止传递,是钾离子通道的一个普遍特征。它对它们的功能至关重要,失活中的故障会导致许多病理。与n型失活不同,c型失活的详细机制仍然是一个活跃的研究领域。晶体学、计算模拟和核磁共振极大地丰富了我们对这一过程的理解。在此,我们回顾了关于c型失活的主要假设,特别关注核磁共振研究对原核钾通道KcsA所起的关键作用,KcsA是哺乳动物电压门控通道的良好模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Structural Biology: X
Journal of Structural Biology: X Biochemistry, Genetics and Molecular Biology-Structural Biology
CiteScore
6.50
自引率
0.00%
发文量
20
审稿时长
62 days
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