Reward Contributions to Serotonergic Functions.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Zhixiang Liu, Rui Lin, Minmin Luo
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引用次数: 34

Abstract

The brain serotonin systems participate in numerous aspects of reward processing, although it remains elusive how exactly serotonin signals regulate neural computation and reward-related behavior. The application of optogenetics and imaging techniques during the last decade has provided many insights. Here, we review recent progress on the organization and physiology of the dorsal raphe serotonin neurons and the relationships between their activity and behavioral functions in the context of reward processing. We also discuss several interesting theories on serotonin's function and how these theories may be reconciled by the possibility that serotonin, acting in synergy with coreleased glutamate, tracks and calculates the so-called beneficialness of the current state to guide an animal's behavior in dynamic environments.

奖励对血清素功能的贡献。
大脑血清素系统参与了奖励处理的许多方面,尽管血清素信号如何准确地调节神经计算和奖励相关行为仍是一个谜。在过去的十年中,光遗传学和成像技术的应用提供了许多见解。本文综述了中缝背5 -羟色胺神经元的组织和生理特征,以及它们在奖赏处理过程中的活动与行为功能之间的关系。我们还讨论了几个关于血清素功能的有趣理论,以及这些理论如何与血清素与共同释放的谷氨酸协同作用的可能性相协调,追踪和计算当前状态的所谓有益性,以指导动物在动态环境中的行为。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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