Shaping Organs: Shared Structural Principles Across Kingdoms.

IF 11.4 1区 生物学 Q1 CELL BIOLOGY
O Hamant, T E Saunders
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引用次数: 24

Abstract

Development encapsulates the morphogenesis of an organism from a single fertilized cell to a functional adult. A critical part of development is the specification of organ forms. Beyond the molecular control of morphogenesis, shape in essence entails structural constraints and thus mechanics. Revisiting recent results in biophysics and development, and comparing animal and plant model systems, we derive key overarching principles behind the formation of organs across kingdoms. In particular, we highlight how growing organs are active rather than passive systems and how such behavior plays a role in shaping the organ. We discuss the importance of considering different scales in understanding how organs form. Such an integrative view of organ development generates new questions while calling for more cross-fertilization between scientific fields and model system communities.

塑造器官:跨王国共享的结构原则。
发育囊括了有机体从单个受精卵到功能性成体的形态发生过程。发育的一个关键部分是器官形式的规范。除了形态发生的分子控制之外,形状在本质上还需要结构约束和力学约束。回顾生物物理学和发育方面的最新成果,并比较动物和植物模型系统,我们得出了跨王国器官形成背后的关键总体原则。特别是,我们强调生长器官是如何主动而不是被动的系统,以及这种行为如何在塑造器官中发挥作用。我们讨论了在理解器官形成过程中考虑不同尺度的重要性。这种器官发育的综合观点产生了新的问题,同时呼吁在科学领域和模型系统社区之间进行更多的交叉施肥。
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来源期刊
CiteScore
19.50
自引率
0.00%
发文量
21
期刊介绍: The Annual Review of Cell and Developmental Biology, established in 1985, comprehensively addresses major advancements in cell and developmental biology. Encompassing the structure, function, and organization of cells, as well as the development and evolution of cells in relation to both single and multicellular organisms, the journal explores models and tools of molecular biology. As of the current volume, the journal has transitioned from gated to open access through Annual Reviews' Subscribe to Open program, making all articles published under a CC BY license.
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