Recent advances in the discovery of plant-derived antimicrobial natural products to combat antimicrobial resistant pathogens: insights from 2018–2022

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00090c

Sunmin Woo , Lewis Marquez , William J. Crandall , Caitlin J. Risener , Cassandra L. Quave

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引用次数: 1

Abstract

Covering: 2018 to 2022

Antimicrobial resistance (AMR) poses a significant global health threat. There is a rising demand for innovative drug scaffolds and new targets to combat multidrug-resistant bacteria. Before the advent of antibiotics, infections were treated with plants chosen from traditional medicine practices. Of Earth's 374 000 plant species, approximately 9% have been used medicinally, but most species remain to be investigated. This review illuminates discoveries of antimicrobial natural products from plants covering 2018 to 2022. It highlights plant-derived natural products with antibacterial, antivirulence, and antibiofilm activity documented in lab studies. Additionally, this review examines the development of novel derivatives from well-studied parent natural products, as natural product derivatives have often served as scaffolds for anti-infective agents.

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发现植物来源的抗微生物天然产品以对抗抗微生物病原体的最新进展：2018-2022年的见解

涵盖范围：2018年至2022年抗微生物耐药性（AMR）对全球健康构成重大威胁。人们对创新药物支架和对抗耐多药细菌的新靶点的需求不断增加。在抗生素出现之前，感染是用从传统医学中选择的植物治疗的。地球374 000种植物，约9%已被用于医学，但大多数物种仍有待研究。这篇综述阐明了2018年至2022年植物中抗菌天然产物的发现。它强调了实验室研究中记录的具有抗菌、抗毒力和抗生物膜活性的植物衍生天然产物。此外，这篇综述考察了从经过充分研究的母体天然产物中开发新的衍生物，因为天然产物衍生物通常用作抗感染剂的支架。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.