Micosis pulmonares en pacientes con diabetes mellitus. Características clínicas y factores de riesgo

IF 1.5 4区生物学 Q4 MYCOLOGY

Revista Iberoamericana De Micologia Pub Date : 2020-04-01 DOI:10.1016/j.riam.2020.04.002

Alejandro Hernández-Solís , Alejandra Camerino Guerrero , Yesenia Colín Muñoz , Saret Bazán Cuervo , Raúl Cícero Sabido , Arturo Reding-Bernal

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引用次数: 3

Abstract

Background

Diabetes mellitus is a public health problem in Mexico, and the trend of the disease is increasing. From 2000 to 2017, 7.32 million new cases were diagnosed, with pulmonary mycoses being one of the most serious complications.

Aims

To describe the frequency and the clinical characteristics of patients diagnosed with pulmonary mycoses, and to identify the risk factors associated with this entity.

Methods

Case–control study, paired by gender (1:1-3) and age (± 5 years), that analyzed patients with pulmonary mycosis (mucormycosis, histoplasmosis, coccidioidomycosis, blastomycosis, aspergillosis, cryptococcosis, paracoccidioidomycosis) and studied the risk factors present in each patient.

Results

From the 162 patients studied, 56 suffered pulmonary mycosis and 106 were controls. The median of the age was 51 and 50 years for the cases and for the controls, respectively. Multiple logistic regression analysis showed that patients with diabetes mellitus had an odds ratio of 8,3 (p < 0.001), and patients with a history of tuberculosis had an odds ratio of 8,8 (p < 0.001).

Conclusions

Our results show that 52% of the patients with pulmonary mycoses had a history of diabetes mellitus. Diabetes mellitus is a relevant risk factor for pulmonary mycoses, which are usually diagnosed in advanced stages and have a high mortality.

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糖尿病患者肺真菌病。临床特征及危险因素

糖尿病是墨西哥的一个公共卫生问题，而且发病率呈上升趋势。从2000年到2017年，新增确诊病例732万例，其中肺真菌病是最严重的并发症之一。目的描述诊断为肺真菌病的患者的频率和临床特征，并确定与该实体相关的危险因素。方法病例对照研究，按性别(1:1-3)和年龄(±5岁)配对，分析肺真菌病(毛霉病、组织胞浆菌病、球孢子菌病、芽生菌病、曲霉病、隐球菌病、副球孢子菌病)患者，并分析每个患者存在的危险因素。结果162例患者中56例为肺真菌病，106例为对照组。病例和对照组的中位年龄分别为51岁和50岁。多元logistic回归分析显示，糖尿病患者的优势比为8,3 (p <0.001)，有结核病史的患者的优势比为8,8 (p <0.001)。结论结果显示，52%的肺真菌病患者有糖尿病病史。糖尿病是肺真菌病的相关危险因素，通常在晚期诊断出来，死亡率很高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Revista Iberoamericana De Micologia MYCOLOGY-

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

81 days

期刊介绍： Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.