Experimental determination of indoor air concentration of 5-chloro-2-methylisothiazol-3(2H)-one/ 2-methylisothiazol-3(2H)-one (CMIT/MIT) emitted by the use of humidifier disinfectant.

Environmental analysis, health and toxicology Pub Date : 2020-06-01 Epub Date: 2020-06-30 DOI:10.5620/eaht.e2020008
Seon-Kyung Park, Hwi-Soo Seol, Hee-Jin Park, Yoon-Seob Kim, Seung-Hun Ryu, Jaehoon Kim, Suejin Kim, Jong-Hyeon Lee, Jung-Hwan Kwon
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引用次数: 11

Abstract

A mixture of 5-chloro-2-methylisothiazol-3(2H)-one/2-methylisothiazol-3(2H)-one (CMIT/MIT) had been used as an active ingredient in humidifier disinfectants (HDs). Owing to its high reactivity, the atmospheric concentration of CMIT/MIT, following its use in HD, would be lower than expected assuming that it is removed by ventilation only. In order to evaluate the exposure concentration of CMIT/MIT used as an HD, room-scale chamber studies were conducted under plausible use of three different HD doses at air change rates (ACR) of 0.3, 0.5, and 1.0 h-1. Atmospheric CMIT/MIT was sampled using two serial impingers containing deionized water after the attainment of steady state. Water samples in which CMIT/MIT was dissolved were concentrated using a cosolvent evaporation method with efficiencies of 35.5 and 77.9% for CMIT and MIT, respectively. The estimated air concentration, assuming that all the CMIT/MIT is absorbed in deionized water, increased linearly with increasing emission rate, but was independent of the ACR. This indicates that the removal rate of CMIT/MIT via chemical reactions is more than the removal rate by ventilation. Further investigations on homogeneous and heterogeneous chemical reactions of CMIT/MIT under ambient conditions are necessary to understand the actual exposure concentration of the mixture in HD.

Abstract Image

使用加湿器消毒剂对室内空气中5-氯-2-甲基异噻唑-3(2H)- 1 / 2-甲基异噻唑-3(2H)- 1 (CMIT/MIT)浓度的测定
用5-氯-2-甲基异噻唑-3(2H)- 1 /2-甲基异噻唑-3(2H)- 1 (CMIT/MIT)混合物作为加湿器消毒剂(hd)的有效成分。由于其高反应性,CMIT/MIT在HD中使用后,假设仅通过通风去除,其大气浓度将低于预期。为了评估CMIT/MIT作为HD的暴露浓度,在空气变化速率(ACR)为0.3、0.5和1.0 h-1的情况下,进行了三种不同HD剂量的室内研究。在达到稳态后,使用两个含去离子水的连续撞击器对大气CMIT/MIT进行采样。采用共溶剂蒸发法对溶解CMIT/MIT的水样进行浓缩,CMIT和MIT的效率分别为35.5%和77.9%。假设所有的CMIT/MIT都被去离子水吸收,估计的空气浓度随排放率的增加而线性增加,但与ACR无关。这说明化学反应对CMIT/MIT的去除率大于通风的去除率。进一步研究环境条件下CMIT/MIT的均相和非均相化学反应是了解混合物在HD中的实际暴露浓度的必要条件。
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