Flanker Task-Elicited Event-Related Potential Sources Reflect Human Recombinant Erythropoietin Differential Effects on Parkinson's Patients.

IF 2.1 4区医学 Q3 CLINICAL NEUROLOGY

Parkinson's Disease Pub Date : 2020-05-22 eCollection Date: 2020-01-01 DOI:10.1155/2020/8625794

Maria L Bringas Vega, Shengnan Liu, Min Zhang, Ivonne Pedroso Ibañez, Lilia M Morales Chacon, Lidice Galan Garcia, Vanessa Perez Bocourt, Marjan Jahanshahi, Pedro A Valdes-Sosa

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引用次数: 2

Abstract

We used EEG source analysis to identify which cortical areas were involved in the automatic and controlled processes of inhibitory control on a flanker task and compared the potential efficacy of recombinant-human erythropoietin (rHuEPO) on the performance of Parkinson's Disease patients. The samples were 18 medicated PD patients (nine of them received rHuEPO in addition to their usual anti-PD medication through random allocation and the other nine patients were on their regular anti-PD medication only) and 9 age and education-matched healthy controls (HCs) who completed the flanker task with simultaneous EEG recordings. N1 and N2 event-related potential (ERP) components were identified and a low resolution tomography (LORETA) inverse solution was employed to localize the neural generators. Reaction times and errors were increased for the incongruent flankers for PD patients compared to controls. EEG source analysis identified an effect of rHuEPO on the lingual gyri for the early N1 component. N2-related sources in middle cingulate and precuneus were associated with the inhibition of automatic responses evoked by incongruent stimuli differentiated PD and HCs. From our results rHuEPO seems to mediate an effect on N1 sources in lingual gyri but not on behavioural performance. N2-related sources in middle cingulate and precuneus were evoked by incongruent stimuli differentiated PD and HCs.

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侧卫任务引发的事件相关电位源反映了人类重组红细胞生成素对帕金森患者的差异影响。

我们使用脑电图源分析来确定哪些皮质区域参与了侧卫任务中抑制控制的自动和受控过程，并比较了重组人促红细胞生成素(rHuEPO)对帕金森病患者表现的潜在功效。样本包括18名接受药物治疗的PD患者(其中9名患者通过随机分配在常规抗PD药物的基础上接受rHuEPO治疗，其他9名患者仅接受常规抗PD药物治疗)和9名年龄和教育程度相匹配的健康对照组(hc)，他们完成了侧卫任务，同时进行了脑电图记录。识别N1和N2事件相关电位(ERP)分量，并采用低分辨率断层扫描(LORETA)逆解定位神经发生器。与对照组相比，PD患者侧侧不一致的反应时间和错误增加。脑电图源分析确定rHuEPO对舌回早期N1成分的影响。中扣带和楔前叶的n2相关源与不一致刺激引起的PD和hc分化的自动反应抑制有关。从我们的结果来看，rHuEPO似乎介导了舌回中N1源的影响，但对行为表现没有影响。不一致刺激诱发了中扣带和楔前叶的n2相关源，分化了PD和hc。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Parkinson's Disease CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

3.10%

发文量

审稿时长

18 weeks

期刊介绍： Parkinson’s Disease is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinson’s disease.