Calorie Restriction and Aging in Humans.

IF 12.6 2区 医学 Q1 NUTRITION & DIETETICS
Annual review of nutrition Pub Date : 2020-09-23 Epub Date: 2020-06-19 DOI:10.1146/annurev-nutr-122319-034601
Emily W Flanagan, Jasper Most, Jacob T Mey, Leanne M Redman
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引用次数: 78

Abstract

Calorie restriction (CR), the reduction of dietary intake below energy requirements while maintaining optimal nutrition, is the only known nutritional intervention with the potential to attenuate aging. Evidence from observational, preclinical, and clinical trials suggests the ability to increase life span by 1-5 years with an improvement in health span and quality of life. CR moderates intrinsic processes of aging through cellular and metabolic adaptations and reducing risk for the development of many cardiometabolic diseases. Yet, implementation of CR may require unique considerations for the elderly and other specific populations. The objectives of this review are to summarize the evidence for CR to modify primary and secondary aging; present caveats for implementation in special populations; describe newer, alternative approaches that have comparative effectiveness and fewer deleterious effects; and provide thoughts on the future of this important field of study.

卡路里限制与人类衰老
热量限制(CR),即在保持最佳营养的同时将膳食摄入量减少到能量需求以下,是已知唯一有可能延缓衰老的营养干预措施。来自观察性、临床前和临床试验的证据表明,有能力延长1-5年的寿命,改善健康寿命和生活质量。CR通过细胞和代谢适应调节衰老的内在过程,并降低许多心脏代谢疾病的发展风险。然而,实施CR可能需要对老年人和其他特定人群进行独特的考虑。本综述的目的是总结CR改变原发性和继发性衰老的证据;提出在特殊人群中实施的注意事项;描述具有相对有效性和较少有害影响的更新的替代方法;并对这一重要研究领域的未来提出一些看法。
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来源期刊
Annual review of nutrition
Annual review of nutrition 医学-营养学
CiteScore
15.80
自引率
0.00%
发文量
19
期刊介绍: Annual Review of Nutrition Publication History:In publication since 1981 Scope:Covers significant developments in the field of nutrition Topics Covered Include: Energy metabolism; Carbohydrates; Lipids; Proteins and amino acids; Vitamins; Minerals; Nutrient transport and function; Metabolic regulation; Nutritional genomics; Molecular and cell biology; Clinical nutrition; Comparative nutrition; Nutritional anthropology; Nutritional toxicology; Nutritional microbiology; Epidemiology; Public health nutrition
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