The occurrence of cancer in vertebrates: a mini review.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-06-08 eCollection Date: 2020-12-01 DOI:10.1186/s40709-020-00119-0

Christos V Kitsoulis, Athanasios D Baxevanis, Theodore J Abatzopoulos

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引用次数: 12

Abstract

Neoplasia is a multilevel condition caused by irregularities over the genome, which can lead to a fatal result. To fully understand this phenomenon, an evolutionary challenge has risen during the last decades, away from human limits, driving the scientific quest into the wild life. The study of wild vertebrate populations in their natural habitats has shown that cancer is rather prominent. Thus, the diversity of vertebrates reported with some form of neoplasia is quite scattered through a variety of habitats. However, some species constitute exceptions by exhibiting cancer-protective features, driven by certain loci in their DNA. It is obvious that from an evolutionary standpoint, the incidence of cancer in different taxa is nowadays studied by seeking for patterns and their roots. The main purpose of the evolutionary approach is no other than to answer a fundamental question: Could cancer be ultimately regarded as another evolutionary force conducive to the formation or shaping-up of species?

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癌症在脊椎动物中的发生:一个小回顾。

肿瘤是由基因组的不规则性引起的多层次疾病，可能导致致命的结果。为了充分理解这一现象，在过去的几十年里，一项进化挑战已经兴起，超越了人类的极限，将科学探索推向了野生动物。对自然栖息地的野生脊椎动物种群的研究表明，癌症是相当突出的。因此，在各种栖息地中，报告的具有某种形式肿瘤的脊椎动物的多样性相当分散。然而，一些物种通过表现出癌症保护特征构成例外，这是由它们DNA中的某些位点驱动的。很明显，从进化的角度来看，现在研究不同分类群的癌症发病率是通过寻找模式和它们的根源。进化方法的主要目的无非是为了回答一个基本问题:癌症最终能否被视为另一种有利于物种形成或形成的进化力量?

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.