Congenital cutaneous candidiasis associated with maternal peripartum candidemia

IF 1.5 4区 生物学 Q4 MYCOLOGY
Mario Fernández-Ruiz , Rocío Mosqueda-Peña , Ana Pérez-Ayala , Daniel Blázquez-Gamero
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引用次数: 3

Abstract

Background

Cutaneous congenital candidiasis (CCC) is a rare condition consisting of invasive fungal infection of the epidermis and dermis that mostly affects preterm infants. Maternal vaginal candidiasis is present in half of the cases, although the occurrence of invasive candidiasis during pregnancy or peripartum period is exceptional.

Case report

We present the case of a full-term infant that was born by vacuum-assisted vaginal delivery to an apparently healthy 33 year-old woman with no history of intravenous drug use or vaginal candidiasis during pregnancy. The newborn showed a diffuse maculopapular rash with respiratory distress and bilateral interstitial lung infiltrates, requiring nasal continuous positive airway pressure support. Blood cultures obtained from the mother due to intrapartum fever yielded Candida albicans. Cultures of vaginal discharge and neonate skin also yielded C. albicans with the same in vitro susceptibly pattern. No alternative source for candidemia was identified. The clinical course after starting a systemic antifungal therapy was favorable in both the mother and the neonate, with clearance of candidemia and resolution of the skin lesions.

Conclusions

CCC must be considered in full-term newborns with maculopapular rash at birth or during the first days of life. The absence of alternative sources for bloodstream infection in the present case suggests a potential etiopathogenic relationship between CCC and maternal candidemia. It is reasonable to rule out postpartum candidemia when CCC is suspected.

先天性皮肤念珠菌病与母体围产期念珠菌血症相关
背景:皮肤先天性念珠菌病(CCC)是一种罕见的由表皮和真皮侵袭性真菌感染组成的疾病,主要影响早产儿。产妇阴道念珠菌病存在于一半的病例中,尽管在怀孕或围产期发生侵袭性念珠菌病是例外。病例报告我们提出一个足月婴儿的情况下,由真空辅助阴道分娩出生的一个健康的33岁妇女,在怀孕期间没有静脉吸毒或阴道念珠菌病的历史。新生儿表现为弥漫性黄斑丘疹伴呼吸窘迫及双侧肺间质浸润,需要鼻腔持续气道正压支持。因产热从母亲处获得的血培养产生白色念珠菌。阴道分泌物和新生儿皮肤的培养也产生了相同的体外敏感模式的白色念珠菌。没有确定念珠菌的替代来源。开始全身抗真菌治疗后的临床过程对母亲和新生儿都是有利的,念珠菌清除和皮肤病变消退。结论足月新生儿在出生时或出生初期出现黄斑丘疹时,必须考虑sccc。本病例缺乏血液感染的替代来源,提示CCC与母体念珠菌之间存在潜在的致病关系。当怀疑有CCC时,排除产后念珠菌是合理的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.90
自引率
0.00%
发文量
17
审稿时长
81 days
期刊介绍: Revista Iberoamericana de Micología (Ibero-American Journal of Mycology) is the official journal of the Asociación Española de Micología, Asociación Venezolana de Micología and Asociación Argentina de Micología (The Spanish, Venezuelan, and Argentinian Mycology Associations). The Journal gives priority to publishing articles on studies associated with fungi and their pathogenic action on humans and animals, as well as any scientific studies on any aspect of mycology. The Journal also publishes, in Spanish and in English, original articles, reviews, mycology forums, editorials, special articles, notes, and letters to the editor, that have previously gone through a scientific peer review process.
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