Engineering fungal terpene biosynthesis

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2023-01-01 DOI:10.1039/d2np00020b

Zhiyong Yin , Jeroen S. Dickschat

引用次数: 5

Abstract

Covering: 2015 to 2022

Fungal terpenoids are of large structural diversity and often exhibit interesting biological activities. Recent work has focused on two main aspects: (1) the discovery and understanding of unknown biosynthetic genes and pathways, and (2) the usage of already known biosynthetic genes in the construction of high yielding production strains. Both aspects will be covered in this review article that aims to summarise the most important work of the past few years.

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工程真菌萜烯生物合成

涵盖范围：2015年至2022年，真菌萜类化合物具有很大的结构多样性，经常表现出有趣的生物活性。最近的工作主要集中在两个方面：（1）发现和理解未知的生物合成基因和途径，以及（2）利用已知的生物合成基因构建高产菌株。这篇综述文章将涵盖这两个方面，旨在总结过去几年最重要的工作。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.