Finding activity through rigidity: syntheses of natural products containing tricyclic bridgehead carbon centers

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2023-04-17 DOI:10.1039/D3NP00008G

Zhi Xu, Xin Li, John A. Rose and Seth B. Herzon

引用次数: 1

Abstract

Covering: up to 2022

Tricyclic bridgehead carbon centers (TBCCs) are a synthetically challenging substructure found in many complex natural products. Here we review the syntheses of ten representative families of TBCC-containing isolates, with the goal of outlining the strategies and tactics used to install these centers, including a discussion of the evolution of the successful synthetic design. We provide a summary of common strategies to inform future synthetic endeavors.

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通过刚性寻找活性:含三环桥头堡碳中心的天然产物的合成

三环桥头堡碳中心(TBCCs)是一种具有合成挑战性的亚结构，存在于许多复杂的天然产物中。在这里，我们回顾了10个具有代表性的含tbcc分离物家族的合成，目的是概述安装这些中心的策略和策略，包括讨论成功合成设计的演变。我们提供了一个共同策略的总结，以告知未来的综合努力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.