Oligodendroglial glycolipids in (Re)myelination: implications for multiple sclerosis research

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2021-05-01 DOI:10.1039/d0np00093k

Luise Nowack , Charlotte S. Teschers , Stefanie Albrecht , Ryan Gilmour

引用次数: 2

Abstract

Covering: up to 2020

This short review surveys aspects of glycolipid-based natural products and their biological relevance in multiple sclerosis (MS). The role of isolated gangliosides in disease models is discussed together with an overview of ganglioside-inspired small molecule drugs and imaging probes. The discussion is extended to neurodegeneration in a more general context and addresses the need for more efficient synthetic methods to generate (glyco)structures that are of therapeutic relevance.

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(再)髓鞘形成中的少突胶质糖脂:对多发性硬化症研究的影响

这篇简短的综述调查了基于糖脂的天然产物及其在多发性硬化症(MS)中的生物学相关性。本文讨论了分离的神经节苷脂在疾病模型中的作用，并概述了神经节苷脂激发的小分子药物和成像探针。讨论扩展到更一般的背景下的神经退行性变，并解决了需要更有效的合成方法来产生(糖)结构的治疗相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.