Increased anxiety-related behavior in mice following β-citronellol inhalation.

IF 16.4 1区 化学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Hiroshi Ueno, Atsumi Shimada, Shunsuke Suemitsu, Shinji Murakami, Naoya Kitamura, Kenta Wani, Yu Takahashi, Yosuke Matsumoto, Motoi Okamoto, Takeshi Ishihara
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引用次数: 4

Abstract

β-Citronellol is a monoterpene alcohol found in essential oils of various aromatic plant species. The physiological effects of β-citronellol inhalation on the central nervous system remain unclear. We investigated the effects of β-citronellol inhalation on mouse behavior. First, we examined whether the odor of β-citronellol was attractive or repellent to mice. Then, following 30 minutes of β-citronellol inhalation, a series of behavioral tests (elevated plus maze, open field, Y-maze, tail suspension, and forced swim tests) were performed. Mice were neither attracted to nor repelled by β-citronellol. Mice that inhaled β-citronellol showed an increase in anxiety-like behavior in the elevated plus maze and open field tests. Performance in the Y-maze and forced swim tests was not affected. These results indicate that β-citronellol acts on the central nervous system of mice following inhalation and increases anxiety. Essential oils and cosmetics containing β-citronellol should be used with caution.

Abstract Image

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吸入β-香茅罗后小鼠焦虑相关行为增加。
β-香茅醇是一种单萜醇,存在于各种芳香植物的精油中。吸入β-香茅醇对中枢神经系统的生理作用尚不清楚。我们研究了吸入β-香茅醇对小鼠行为的影响。首先,我们研究了β-香茅醇的气味对小鼠是吸引还是排斥。然后,在吸入β-香茅醇30分钟后,进行一系列行为测试(高架+迷宫、开阔场、y形迷宫、悬尾和强迫游泳测试)。小鼠既不被β-香茅醇吸引也不排斥。吸入β-香茅醇的小鼠在高架迷宫和开阔场地试验中表现出焦虑样行为的增加。在y形迷宫和强迫游泳测试中的表现不受影响。这些结果表明,β-香茅醛吸入后对小鼠中枢神经系统起作用,并增加焦虑。含有β-香茅醇的精油和化妆品应谨慎使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Accounts of Chemical Research
Accounts of Chemical Research 化学-化学综合
CiteScore
31.40
自引率
1.10%
发文量
312
审稿时长
2 months
期刊介绍: Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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