Clinicopathologic Features and Outcome of Adenocarcinoma of the Anal Canal: A Population-Based Study.

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2020-05-13 eCollection Date: 2020-01-01 DOI:10.1155/2020/5139236
Shekhar Gogna, Roberto Bergamaschi, Agon Kajmolli, Mahir Gachabayov, Aram Rojas, David Samson, Rifat Latifi, Xiang Da Dong
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引用次数: 2

Abstract

Background: Anal canal adenocarcinoma (AA) is an uncommon tumor of the gastrointestinal tract. We seek to provide a detailed description of the incidence, demographics, and outcome of this rare tumor in the United States.

Methods: The data on anal canal adenocarcinoma from SEER Program, between 1973-2015, were extracted. We analyzed the incidence rates by demographics and tumor characteristics, followed by analysis of its impact on survival.

Results: The incidence of AA increased initially by 4.03% yearly from 1973 to 1985 but had a modest decline of 0.32% annually thereafter. The mean age for diagnosis of AA was 68.12 ± 14.02 years. Males outnumbered females by 54.8 to 45.2%. Tumors were mostly localized on presentation (44.4%) and moderately differentiated (41.1%). Age generally correlated with poor overall cancer survival. However, young patients (age <40 years) also showed poor long-term survival. Patients with localized disease and well-differentiated tumors showed better survival outcomes. Surgical intervention improved survival significantly as compared to patients who did not (116.7 months vs 42.7 months, p < 0.01).

Conclusions: Anal canal adenocarcinoma demonstrated a poor bimodal cancer-free survival in both younger and older patient groups. Surgery significantly improves odds of survival and should be offered to patients amenable to intervention.

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肛管腺癌的临床病理特征和预后:一项基于人群的研究。
背景:肛管腺癌(AA)是一种罕见的胃肠道肿瘤。我们试图提供美国这种罕见肿瘤的发病率、人口统计学和预后的详细描述。方法:提取1973-2015年SEER项目肛管腺癌的资料。我们分析了人口统计学和肿瘤特征的发病率,然后分析了其对生存的影响。结果:1973 - 1985年AA发病率以每年4.03%的速度递增,此后每年缓慢下降0.32%。AA的平均诊断年龄为68.12±14.02岁。男性比女性多54.8%,占45.2%。肿瘤大多局限于表现(44.4%)和中度分化(41.1%)。年龄通常与较差的总体癌症生存率相关。而年轻患者(年龄p < 0.01)。结论:肛管腺癌在年轻和老年患者组中均表现出较差的双峰无癌生存率。手术可显著提高生存几率,应提供给可接受干预的患者。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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