Making iron-sulfur cluster: structure, regulation and evolution of the bacterial ISC system.

2区生物学 Q1 Biochemistry, Genetics and Molecular Biology

Advances in Microbial Physiology Pub Date : 2020-01-01 Epub Date: 2020-04-16 DOI:10.1016/bs.ampbs.2020.01.001

Corentin Baussier, Soufyan Fakroun, Corinne Aubert, Sarah Dubrac, Pierre Mandin, Béatrice Py, Frédéric Barras

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引用次数: 23

Abstract

Iron sulfur (Fe-S) clusters rank among the most ancient and conserved prosthetic groups. Fe-S clusters containing proteins are present in most, if not all, organisms. Fe-S clusters containing proteins are involved in a wide range of cellular processes, from gene regulation to central metabolism, via gene expression, RNA modification or bioenergetics. Fe-S clusters are built by biogenesis machineries conserved throughout both prokaryotes and eukaryotes. We focus mostly on bacterial ISC machinery, but not exclusively, as we refer to eukaryotic ISC system when it brings significant complementary information. Besides covering the structural and regulatory aspects of Fe-S biogenesis, this review aims to highlight Fe-S biogenesis facets remaining matters of discussion, such as the role of frataxin, or the link between fatty acid metabolism and Fe-S homeostasis. Last, we discuss recent advances on strategies used by different species to make and use Fe-S clusters in changing redox environmental conditions.

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制造铁硫簇：细菌 ISC 系统的结构、调节和进化。

铁硫（Fe-S）簇是最古老、最保守的修复基团之一。含有蛋白质的 Fe-S 簇存在于大多数甚至所有生物体中。含铁-S簇的蛋白质通过基因表达、RNA修饰或生物能，参与了从基因调控到中心代谢等多种细胞过程。Fe-S簇是由原核生物和真核生物中一致的生物发生机制构建的。我们主要关注细菌 ISC 机制，但并不局限于此，因为当真核生物 ISC 系统带来重要的补充信息时，我们也会参考。除了涉及 Fe-S 生物发生的结构和调控方面，本综述还旨在强调仍在讨论的 Fe-S 生物发生方面的问题，如 frataxin 的作用或脂肪酸代谢与 Fe-S 平衡之间的联系。最后，我们讨论了不同物种在不断变化的氧化还原环境条件下制造和使用 Fe-S 簇的策略的最新进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Microbial Physiology 生物-生化与分子生物学

CiteScore

6.20

自引率

0.00%

发文量

期刊介绍： Advances in Microbial Physiology publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to traditional views of whole cell physiology.