Regulation of vascular tone by transient receptor potential ankyrin 1 channels.

4区 生物学 Q4 Biochemistry, Genetics and Molecular Biology
Current topics in membranes Pub Date : 2020-01-01 Epub Date: 2020-02-29 DOI:10.1016/bs.ctm.2020.01.009
Pratish Thakore, Sher Ali, Scott Earley
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引用次数: 6

Abstract

The Ca2+-permeable, non-selective cation channel, TRPA1 (transient receptor potential ankyrin 1), is the sole member of the ankyrin TRP subfamily. TRPA1 channels are expressed on the plasma membrane of neurons as well as non-neuronal cell types, such as vascular endothelial cells. TRPA1 is activated by electrophilic compounds, including dietary molecules such as allyl isothiocyanate, a derivative of mustard. Endogenously, the channel is thought to be activated by reactive oxygen species and their metabolites, such as 4-hydroxynonenal (4-HNE). In the context of the vasculature, activation of TRPA1 channels results in a vasodilatory response mediated by two distinct mechanisms. In the first instance, TRPA1 is expressed in sensory nerves of the vasculature and, upon activation, mediates release of the potent dilator, calcitonin gene-related peptide (CGRP). In the second, work from our laboratory has demonstrated that TRPA1 is expressed in the endothelium of blood vessels exclusively in the cerebral vasculature, where its activation produces a localized Ca2+ signal that results in dilation of cerebral arteries. In this chapter, we provide an in-depth overview of the biophysical and pharmacological properties of TRPA1 channels and their importance in regulating vascular tone.

瞬时受体电位锚蛋白1通道对血管张力的调节。
Ca2+可渗透的非选择性阳离子通道TRPA1(瞬时受体电位锚蛋白1)是锚蛋白TRP亚家族的唯一成员。TRPA1通道既表达于神经元的质膜上,也表达于非神经元细胞类型如血管内皮细胞上。TRPA1被亲电化合物激活,包括膳食分子,如异硫氰酸烯丙酯,一种芥菜的衍生物。内源性,该通道被活性氧及其代谢物(如4-羟基壬烯醛(4-HNE))激活。在脉管系统中,TRPA1通道的激活导致由两种不同机制介导的血管舒张反应。首先,TRPA1在脉管感觉神经中表达,激活后介导强效扩张剂降钙素基因相关肽(CGRP)的释放。在第二项研究中,我们实验室的工作已经证明TRPA1仅在脑血管血管内皮中表达,其激活产生局部Ca2+信号,导致脑动脉扩张。在本章中,我们将深入概述TRPA1通道的生物物理和药理学特性及其在调节血管张力中的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current topics in membranes
Current topics in membranes 生物-生化与分子生物学
CiteScore
3.50
自引率
0.00%
发文量
10
审稿时长
>12 weeks
期刊介绍: Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology.
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