Origins and Immunity Networking Functions of EDS1 Family Proteins.

IF 9.1 1区 农林科学 Q1 PLANT SCIENCES
Annual review of phytopathology Pub Date : 2020-08-25 Epub Date: 2020-05-12 DOI:10.1146/annurev-phyto-010820-012840
Dmitry Lapin, Deepak D Bhandari, Jane E Parker
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引用次数: 90

Abstract

The EDS1 family of structurally unique lipase-like proteins EDS1, SAG101, and PAD4 evolved in seed plants, on top of existing phytohormone and nucleotide-binding-leucine-rich-repeat (NLR) networks, to regulate immunity pathways against host-adapted biotrophic pathogens. Exclusive heterodimers between EDS1 and SAG101 or PAD4 create essential surfaces for resistance signaling. Phylogenomic information, together with functional studies in Arabidopsis and tobacco, identify a coevolved module between the EDS1-SAG101 heterodimer and coiled-coil (CC) HET-S and LOP-B (CCHELO) domain helper NLRs that is recruited by intracellular Toll-interleukin1-receptor (TIR) domain NLR receptors to confer host cell death and pathogen immunity. EDS1-PAD4 heterodimers have a different and broader activity in basal immunity that transcriptionally reinforces local and systemic defenses triggered by various NLRs. Here, we consider EDS1 family protein functions across seed plant lineages in the context of networking with receptor and helper NLRs and downstream resistance machineries. The different modes of action and pathway connectivities of EDS1 family members go some way to explaining their central role in biotic stress resilience.

EDS1家族蛋白的起源和免疫网络功能
EDS1家族结构独特的脂酶样蛋白EDS1, SAG101和PAD4在种子植物中进化,在现有的植物激素和核苷酸结合-亮氨酸富重复(NLR)网络的基础上,调节对宿主适应的生物营养病原体的免疫途径。EDS1和SAG101或PAD4之间的异源二聚体为抗性信号传递创造了必要的表面。系统基因组信息,结合拟南芥和烟草的功能研究,确定了EDS1-SAG101异源二聚体与卷曲卷曲(CC) HET-S和LOP-B (CCHELO)结构域辅助NLR之间的共同进化模块,该模块被细胞内toll -白细胞介素1受体(TIR)结构域NLR受体募集,从而赋予宿主细胞死亡和病原体免疫。EDS1-PAD4异源二聚体在基础免疫中具有不同且更广泛的活性,可通过转录增强由各种nlr触发的局部和全身防御。在这里,我们考虑了EDS1家族蛋白在种子植物谱系中与受体和辅助NLRs以及下游抗性机制联网的功能。EDS1家族成员的不同作用模式和通路连接在一定程度上解释了它们在生物应激恢复中的核心作用。
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来源期刊
Annual review of phytopathology
Annual review of phytopathology 生物-植物科学
CiteScore
16.60
自引率
1.00%
发文量
19
期刊介绍: The Annual Review of Phytopathology, established in 1963, covers major advancements in plant pathology, including plant disease diagnosis, pathogens, host-pathogen Interactions, epidemiology and ecology, breeding for resistance and plant disease management, and includes a special section on the development of concepts. The journal is now open access through Annual Reviews' Subscribe to Open program, with articles published under a CC BY license.
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