Fungal–fungal co-culture: a primer for generating chemical diversity†

IF 10.6 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2022-01-01 DOI:10.1039/d1np00070e

Sonja L. Knowles , Huzefa A. Raja , Christopher D. Roberts , Nicholas H. Oberlies

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引用次数: 23

Abstract

Covering: 2002 to 2020

In their natural environment, fungi must compete for resources. It has been hypothesized that this competition likely induces the biosynthesis of secondary metabolites for defence. In a quest to discover new chemical diversity from fungal cultures, a growing trend has been to recapitulate this competitive environment in the laboratory, essentially growing fungi in co-culture. This review covers fungal–fungal co-culture studies beginning with the first literature report in 2002. Since then, there has been a growing number of new secondary metabolites reported as a result of fungal co-culture studies. Specifically, this review discusses and provides insights into (1) rationale for pairing fungal strains, (2) ways to grow fungi for co-culture, (3) different approaches to screening fungal co-cultures for chemical diversity, (4) determining the secondary metabolite-producing strain, and (5) final thoughts regarding the fungal–fungal co-culture approach. Our goal is to provide a set of practical strategies for fungal co-culture studies to generate unique chemical diversity that the natural products research community can utilize.

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真菌-真菌共培养:产生化学多样性的引物

在自然环境中，真菌必须竞争资源。据推测，这种竞争可能会诱导次生代谢物的生物合成以进行防御。为了从真菌培养中发现新的化学多样性，一个日益增长的趋势是在实验室中重现这种竞争环境，本质上是在共培养中培养真菌。本文综述了真菌-真菌共培养的研究，从2002年的第一篇文献报道开始。从那时起，由于真菌共培养研究的结果，越来越多的新的次生代谢物被报道。具体来说，本文讨论并提供了以下方面的见解:(1)配对真菌菌株的基本原理，(2)培养真菌共培养的方法，(3)筛选真菌共培养物化学多样性的不同方法，(4)确定次生代谢物产生菌株，以及(5)关于真菌-真菌共培养方法的最终想法。我们的目标是为真菌共培养研究提供一套实用的策略，以产生天然产物研究界可以利用的独特化学多样性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.