LINK-A long non-coding RNA and VEGF RNA expression in epithelial ovarian cancer patients.

Q3 Medicine

Human Antibodies Pub Date : 2020-01-01 DOI:10.3233/HAB-200411

Parichehr Maleki, Sadaf Valeh Sheida, Seyed Javad Mowla, Vahid Soleimani, Mohammad Taheri, Jamshid Raheb

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引用次数: 4

Abstract

LINK-A (long intergenic non-coding RNA for kinase activation) is a newly identified long non-coding RNA with oncogenic function, which leads to the hyperactivation of AKT and HIF1α. thereby, fosters cell proliferation, mobility and metastasis. VEGF (vascular endothelial growth factor), a well-known cytokine has an important role in angiogenesis. In this study, we quantified RNA expression of LINK-A and VEGF on 45 tumor specimens obtained from Iranian patients diagnosed with Epithelial Ovarian Cancer (EOC). Our goal was to evaluate expression of LINK-A lncRNA and VEGF mRNA in ovarian cancer tissues and find the probable correlation of LINK-A with VEGF as a major transcription target for HIF1α. LINK-A and VEGF were remarkably overexpressed in EOC tissues compared to normal tissues (P value: 0.004, 0.0001, respectively), but we did not find correlation between LINK-A and VEGF RNA expressions in this study. LINK-A was significantly overexpressed in higher stages of cancer and tumor grades. VEGF was only significantly elevated in higher stages. This study confirms importance of novel lncRNA of LINK-A in Iranian EOC patients.

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长链非编码RNA和VEGF RNA在上皮性卵巢癌患者中的表达。

LINK-A (long - intergenic non-coding RNA for kinase activation)是一种新发现的具有致癌功能的长链非编码RNA，可导致AKT和HIF1α的过度激活。从而促进细胞增殖、移动和转移。血管内皮生长因子(VEGF)是一种众所周知的细胞因子，在血管生成中起着重要作用。在这项研究中，我们量化了45例伊朗上皮性卵巢癌(EOC)患者肿瘤标本中LINK-A和VEGF的RNA表达。我们的目标是评估LINK-A lncRNA和VEGF mRNA在卵巢癌组织中的表达，并发现LINK-A与VEGF作为HIF1α的主要转录靶点的可能相关性。与正常组织相比，在EOC组织中LINK-A和VEGF明显过表达(P值分别为0.004和0.0001)，但我们在本研究中未发现LINK-A和VEGF RNA表达之间的相关性。LINK-A在较高分期和肿瘤分级中显著过表达。VEGF仅在较高分期显著升高。本研究证实了LINK-A的新型lncRNA在伊朗EOC患者中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Human Antibodies Medicine-Immunology and Allergy

CiteScore

3.50

自引率

0.00%

发文量

期刊介绍： Human Antibodies is an international journal designed to bring together all aspects of human hybridomas and antibody technology under a single, cohesive theme. This includes fundamental research, applied science and clinical applications. Emphasis in the published articles is on antisera, monoclonal antibodies, fusion partners, EBV transformation, transfections, in vitro immunization, defined antigens, tissue reactivity, scale-up production, chimeric antibodies, autoimmunity, natural antibodies/immune response, anti-idiotypes, and hybridomas secreting interesting growth factors. Immunoregulatory molecules, including T cell hybridomas, will also be featured.