Cholino-ncRNAs modulate sex-specific- and age-related acetylcholine signals.

IF 3 4区 生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
FEBS Letters Pub Date : 2020-07-01 Epub Date: 2020-05-04 DOI:10.1002/1873-3468.13789
Nimrod Madrer, Hermona Soreq
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引用次数: 14

Abstract

Acetylcholine (ACh) signaling orchestrates mammalian movement, mental capacities, and inflammation. Dysregulated ACh signaling associates with many human mental disorders and neurodegeneration in an individual-, sex-, and tissue-related manner. Moreover, aged patients under anticholinergic therapy show increased risk of dementia, but the underlying molecular mechanisms are incompletely understood. Here, we report that certain cholinergic-targeting noncoding RNAs, named Cholino-noncoding RNAs (ncRNAs), can modulate ACh signaling, agonistically or antagonistically, via distinct direct and indirect mechanisms and at different timescales. Cholino-ncRNAs include both small microRNAs (miRNAs) and long noncoding RNAs (lncRNAs). The former may attenuate translation and/or induce destruction of target mRNAs that code for either ACh-signaling proteins or transcription factors controlling the expression of cholinergic genes. lncRNAs may block miRNAs via 'sponging' events or by competitive binding to the cholinergic target mRNAs. Also, single nucleotide polymorphisms in either Cholino-ncRNAs or in their recognition sites in the ACh-signaling associated genes may modify ACh signaling-regulated processes. Taken together, both inherited and acquired changes in the function of Cholino-ncRNAs impact ACh-related deficiencies, opening new venues for individual, sex-related, and age-specific oriented research, diagnosis, and therapeutics.

Abstract Image

Abstract Image

Abstract Image

胆碱- ncrnas调节性别特异性和年龄相关的乙酰胆碱信号。
乙酰胆碱(ACh)信号调控哺乳动物的运动、心智能力和炎症。乙酰胆碱信号失调与许多人类精神障碍和神经退行性疾病以个体、性别和组织相关的方式相关。此外,接受抗胆碱能治疗的老年患者痴呆风险增加,但其潜在的分子机制尚不完全清楚。在这里,我们报道了某些胆碱能靶向非编码rna,称为胆碱非编码rna (ncRNAs),可以通过不同的直接和间接机制和不同的时间尺度,拮抗或拮抗调节乙酰胆碱信号传导。胆碱- ncrna包括小微rna (mirna)和长链非编码rna (lncrna)。前者可能减弱翻译和/或诱导目标mrna的破坏,这些mrna编码ach信号蛋白或控制胆碱能基因表达的转录因子。lncrna可能通过“海绵”事件或通过与胆碱能靶mrna的竞争性结合来阻断mirna。此外,胆碱- ncrna的单核苷酸多态性或乙酰胆碱- ncrna在乙酰胆碱信号传导相关基因中的识别位点也可能改变乙酰胆碱信号传导调节过程。总之,遗传和获得性胆碱- ncrna功能的改变都会影响乙酰胆碱相关缺陷,为个体、性别和年龄特异性的研究、诊断和治疗开辟了新的领域。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
FEBS Letters
FEBS Letters 生物-生化与分子生物学
CiteScore
6.60
自引率
2.90%
发文量
303
审稿时长
1 months
期刊介绍: FEBS Letters is one of the world''s leading journals in molecular biology and is renowned both for its quality of content and speed of production. Bringing together the most important developments in the molecular biosciences, FEBS Letters provides an international forum for Minireviews, Research Letters and Hypotheses that merit urgent publication.
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