Prevalence and Clinical Implications of the Mirror and TV Signs in Advanced Alzheimer's Disease and Dementia with Lewy Bodies.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-03-26 eCollection Date: 2020-01-01 DOI:10.1159/000506510

Yasuhiro Nagahama, Toshiya Fukui, Hiroshi Akutagawa, Hiroko Ohtaki, Momoka Okabe, Tatsuya Ito, Hiroko Suga, Hiroshige Fujishiro

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引用次数: 6

Abstract

Objective: To explore the prevalence and clinical implications of the mirror and TV signs in the moderate to advanced stages of Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).

Methods: We retrospectively examined the prevalence of clinical and psychiatric symptoms including the mirror and TV signs in 200 subjects with AD and 200 with DLB and evaluated the relationships among the symptoms.

Results: The mirror sign was found in 3.0% of AD and 4.5% of DLB subjects. The TV sign was found in 1.5% of AD and 4.0% of DLB subjects. The prevalence of the mirror and TV signs was not significantly different between the AD and DLB groups. Visual hallucination, visual illusion, misidentification of person, and sleep talking were significantly more frequent in DLB than in AD subjects. The mirror sign was significantly associated with lower Mini-Mental State Examination scores, whereas the TV sign was significantly associated with the misidentification of person.

Conclusions: Both the mirror and TV signs were rare even in the moderate to advanced stages of AD and DLB. The mirror sign may be independent from other delusional misidentification syndromes (DMSs). Being associated mainly with global cognitive decline, the mirror sign is unlikely attributed to any specific cognitive impairment or the dysfunction of localized brain areas. In contrast, the TV sign was significantly more often coexistent with the misidentification of person, suggesting that the TV sign may partly share common neuropsychological mechanisms with DMSs.

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晚期阿尔茨海默病和伴路易体痴呆的镜子和电视征象的患病率及临床意义。

目的:探讨中晚期阿尔茨海默病(AD)及伴路易体痴呆(DLB)患者镜象和电视征象的患病率及临床意义。方法:回顾性分析200例AD患者和200例DLB患者的临床和精神症状，包括镜子和电视症状的患病率，并评估症状之间的关系。结果:AD和DLB的镜像征分别为3.0%和4.5%。在1.5%的AD和4.0%的DLB受试者中发现了电视信号。AD组和DLB组之间镜子和电视信号的患病率无显著差异。视幻觉、视错觉、认人错误和梦话在DLB组的发生率明显高于AD组。镜子标志与较低的精神状态测试分数显著相关，而电视标志与误认人显著相关。结论:即使在中晚期AD和DLB患者中，镜象和电视象也很少见。镜像征可能独立于其他妄想性错误识别综合征(dms)。镜像标志主要与整体认知能力下降有关，不太可能归因于任何特定的认知障碍或局部大脑区域的功能障碍。相比之下，电视信号与对人的错误识别更常共存，这表明电视信号可能与dms有部分共同的神经心理机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.