Impact of a two-bacterial-strain formula, containing Bifidobacterium animalis lactis BB-12 and Enterococcus faecium L3, administered before and after therapy for Helicobacter pylori eradication.

Francesco Di Pierro, Alexander Bertuccioli, Mariella Saponara, Leandro Ivaldi
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引用次数: 5

Abstract

Background: Results from the meta-analysis of randomized controlled studies demonstrate that the adjuvant use of probiotics enhances the rate of Helicobacter pylori (Hp) eradication, reducing concomitantly the occurrence of side effects, mainly diarrhea. Bifidobacterium animalis lactis BB-12 and Enterococcus faecium L3 are two bacterial strains reported to clinically improve the rate of Hp eradication, reducing concomitantly the occurrence of side effects.

Methods: Due to our pragmatic and routine use of these two strains as an adjuvant therapy to antibiotics and proton pump inhibitors (PPIs) during attempted Hp eradication, we have analyzed retrospectively their impact on the outcome.

Results: Our results, obtained through a highly pragmatic clinical approach, demonstrate that the probiotic add-on therapy before and after the triple or quadruple therapy to eradicate Hp increases eradication rates and reduces side effects. Moreover, even if observed in only a small cohort of patients, the treatment seems to improve the eubiosis of the gut microbial consortium.

Conclusions: Administration of BB-12 and L3 strains as an adjuvant regimen during Hp eradication therapy has better success than conventional therapy (antibiotics plus a PPI) alone.

在幽门螺杆菌根除治疗前后使用含有乳酸双歧杆菌BB-12和屎肠球菌L3的两种细菌菌株配方的影响
背景:随机对照研究的荟萃分析结果表明,辅助使用益生菌可以提高幽门螺杆菌(Hp)的根除率,减少伴随的副作用,主要是腹泻的发生。动物乳酸双歧杆菌BB-12和屎肠球菌L3是临床报道的两种提高Hp根除率的细菌,同时减少了副作用的发生。方法:由于我们在试图根除Hp时实际和常规使用这两种菌株作为抗生素和质子泵抑制剂(PPIs)的辅助治疗,我们回顾性分析了它们对结果的影响。结果:我们通过高度务实的临床方法获得的结果表明,在三联或四联治疗之前和之后添加益生菌治疗来根除Hp可以提高根除率并减少副作用。此外,即使仅在一小部分患者中观察到,这种治疗似乎也能改善肠道微生物群的益生菌群。结论:在Hp根除治疗期间,使用BB-12和L3菌株作为辅助治疗方案比单独使用常规治疗(抗生素加PPI)更成功。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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