Ahmed Omer Almobarak, Ayat Jervase, Aza Abdelrahman Fadl, Nur Ibrahim Ali Garelnabi, Suzan Al Hakem, Tarig Mohamed Hussein, Amro Ahmad Aljack Ahmad, Inas Salah El-den Ahmed, Safaa Badi, Mohamed H Ahmed
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引用次数: 5
Abstract
Background: The gallstones are common health problem across the world with huge financial burden on health authorities. Obesity and insulin resistance are associated with risk of gallstones disease (GSD). The aim of this study was to assess the prevalence of metabolic syndrome (MetS) and diabetes and associated risk factors in Sudanese patients with gallstones.
Methods: A prospective cross-sectional study, enrolled patients with gallstones attending Ibn Sina Specialized Teaching Hospital for gastrointestinal and hepatobiliary diseases. A structured questionnaire was applied, anthropometric measures were taken, and blood tested for HbA1c, fasting glucose and lipid profile. Data was analysed using SPSS version 23.
Results: A total number of 151 participants were recruited in the study, 71 of them were ultrasound confirmed GSD patients, and the other 80 were controls without GSD over a period of six months. The prevalence of the MetS and diabetes was 30% and 23.9% respectively. Borderline diabetes was 16.9% and overweight and obesity constituted more than half of the sample 59.6%. Using Chi-Square test, a statistically significant association was found between MetS and HDL, TG, LDL level, waist circumference and blood pressure (BP). Absolute predictors and the risk factors for gallstone disease were waist circumference, age, HbA1c and LDL.
Conclusions: The prevalence of MetS and diabetes among gallstone patients was 30% and 23.9% respectively. Absolute predictors and the risk factors for gallstone disease were waist circumference, age, HbA1c and LDL.
背景:胆结石是世界范围内常见的健康问题，给卫生当局带来了巨大的经济负担。肥胖和胰岛素抵抗与胆结石疾病(GSD)的风险相关。本研究的目的是评估苏丹胆结石患者中代谢综合征(MetS)和糖尿病的患病率及相关危险因素。方法:一项前瞻性横断面研究，纳入在伊本新浪胃肠及肝胆疾病专科教学医院就诊的胆结石患者。采用结构化问卷，进行人体测量，血液检测HbA1c、空腹血糖和血脂。数据分析使用SPSS version 23。结果:本研究共招募151名参与者，其中超声确诊GSD患者71人，对照组80人，均为6个月无GSD的对照组。met和糖尿病的患病率分别为30%和23.9%。边缘型糖尿病占16.9%，超重和肥胖占一半以上，占59.6%。经卡方检验，met与HDL、TG、LDL水平、腰围、血压(BP)存在显著相关性。腰围、年龄、HbA1c和LDL是胆结石疾病的绝对预测因子和危险因素。结论:胆结石患者中met和糖尿病的患病率分别为30%和23.9%。腰围、年龄、HbA1c和LDL是胆结石疾病的绝对预测因子和危险因素。
期刊介绍：
Translational Gastroenterology and Hepatology (Transl Gastroenterol Hepatol; TGH; Online ISSN 2415-1289) is an open-access, peer-reviewed online journal that focuses on cutting-edge findings in the field of translational research in gastroenterology and hepatology and provides current and practical information on diagnosis, prevention and clinical investigations of gastrointestinal, pancreas, gallbladder and hepatic diseases. Specific areas of interest include, but not limited to, multimodality therapy, biomarkers, imaging, biology, pathology, and technical advances related to gastrointestinal and hepatic diseases. Contributions pertinent to gastroenterology and hepatology are also included from related fields such as nutrition, surgery, public health, human genetics, basic sciences, education, sociology, and nursing.
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