Drug-resistant tuberculosis: an experience from Qatar.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-12-01 DOI:10.1080/19932820.2020.1744351

Maisa Ali, Faraj Howady, Waqar Munir, Hanfa Karim, Zubaida Al-Suwaidi, Muna Al-Maslamani, Abdullatif Alkhal, Nada Elmaki, Hisham Ziglam

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引用次数: 5

Abstract

This study was conducted to evaluate the characteristics, treatment outcome and risk factors associated with 223 drug-resistant tuberculosis (DR-TB) cases in the State of Qatar. A descriptive records-based retrospective study was conducted on patients registered at Communicable Disease Centre (CDC), Qatar to all consecutive microbiologically confirmed tuberculosis cases for the period January 2010 - March 2015. Demographic, clinical data, drug-resistance pattern of isolated mycobacteria and treatment outcome was assessed for the patient who completed their treatment in Qatar. Of 3301 patients with positive M. tuberculosis culture were analyzed; 223 (6.7%) were resistant to at least one drug. The overall prevalence of multi-d rug resistant TB (MDR-TB) was 1.2% (n = 38) of patients. A former resident of Indian sub contents was the most common demographic characteristic observed (64.1%). The outcome of treatment was assessed for 85 resistant cases with follow-up after completion of treatment. Cure and relapse rates were 97.6%, and 2.4%, respectively. Drug-resistant TB in Qatar is influenced by migration where the patients were probably infected. Rapid sputum sampling performed in the early stages of the disease, patient isolation, and drug-susceptibility testing should be the standard of care.

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耐药结核病:卡塔尔的经验。

本研究旨在评估卡塔尔国223例耐药结核病(DR-TB)病例的特征、治疗结果和相关危险因素。对2010年1月至2015年3月期间在卡塔尔传染病中心(CDC)登记的所有连续微生物学确诊结核病病例进行了基于描述性记录的回顾性研究。对在卡塔尔完成治疗的患者进行人口统计学、临床数据、分离分枝杆菌耐药模式和治疗结果评估。对3301例结核分枝杆菌培养阳性患者进行分析;223例(6.7%)对至少一种药物耐药。耐多药结核病(MDR-TB)的总患病率为1.2% (n = 38)。前印度裔居民是最常见的人口统计学特征(64.1%)。对85例耐药病例的治疗结果进行评估，并在治疗完成后进行随访。治愈率97.6%，复发率2.4%。卡塔尔的耐药结核病受到移民的影响，患者可能是在移民中被感染的。在疾病早期进行快速痰取样、患者隔离和药敏试验应成为标准护理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.