Saving the Breast Saves the Lives of Breast Cancer Patients.

IF 1.6 Q4 ONCOLOGY
International Journal of Surgical Oncology Pub Date : 2020-02-27 eCollection Date: 2020-01-01 DOI:10.1155/2020/8709231
Mohammad Esmaeil Akbari, Maryam Khayamzadeh, Hamid Reza Mirzaei, Afshin Moradi, Atieh Akbari, Farid Moradian, Neda Khalili
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引用次数: 9

Abstract

Introduction. Surgery has been known as the procedure of choice for breast cancer management since 1700 years before Christ. Nowadays, breast-conserving surgery and mastectomy are performed in selected cases with specific clinical criteria. Here, we compare these two procedures for breast cancer patients with variable features in Cancer Research Center, Tehran, as a single institution experience.

Methods: In this 25-year follow-up retrospective cohort study, we identified breast cancer patients who had undergone breast-conserving therapy or mastectomy. Disease-free survival and overall survival were evaluated using Kaplan-Meier survival analysis and the log-rank test between the two groups. A p value less than 0.05 was considered statistically significant.

Results: A total of 3358 breast cancer patients, including 61% breast-conserving therapy and 39% mastectomy cases were identified, with a mean follow-up time of 94 months. The overall survival and disease-free survival of all cases were significantly better in breast-conserved patients, particularly in early-stage breast cancer with favorable clinical, pathological, and biological features. Ten-year disease-free survival and overall survival in breast-conserving therapy and mastectomy cases were 74%, 88% and 58%, 80%, respectively.

Conclusion: Breast-conserving surgery and radiation therapy prove to be an appropriate treatment option for breast cancer patients in terms of overall survival and disease-free survival when indicated.

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拯救乳房拯救乳腺癌患者的生命。
介绍。早在公元前1700年,手术就被认为是治疗乳腺癌的首选方法。如今,保留乳房手术和乳房切除术是在特定临床标准的选定病例中进行的。在这里,我们比较这两种程序的乳腺癌患者的不同特征的癌症研究中心,德黑兰,作为一个单一的机构经验。方法:在这项25年的随访回顾性队列研究中,我们确定了接受保乳治疗或乳房切除术的乳腺癌患者。采用Kaplan-Meier生存分析和两组间log-rank检验评估无病生存期和总生存期。p值小于0.05认为有统计学意义。结果:共发现3358例乳腺癌患者,其中保乳治疗61%,乳房切除术39%,平均随访时间94个月。保乳患者的总生存期和无病生存期明显更好,特别是在具有良好临床、病理和生物学特征的早期乳腺癌患者。保乳治疗和乳房切除术的10年无病生存率和总生存率分别为74%、88%和58%、80%。结论:保乳手术加放疗在总生存期和无病生存期是乳腺癌患者的一种合适的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
0.00%
发文量
5
审稿时长
20 weeks
期刊介绍: International Journal of Surgical Oncology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies in all areas of surgical oncology.
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