Liquid Biopsy: The Unique Test for Chasing the Genetics of Solid Tumors.

IF 4.3 3区 材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC
ACS Applied Electronic Materials Pub Date : 2020-02-28 eCollection Date: 2020-01-01 DOI:10.1177/2516865720904052
Seyed Mohammad Kazem Aghamir, Ramin Heshmat, Mehdi Ebrahimi, Fatemeh Khatami
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引用次数: 0

Abstract

Blood test is a kind of liquid biopsy that checks cancer cells or cancer nucleic acids circulating freely from cells in the blood. A liquid biopsy may be used to distinguish cancer at early stages and it could be a game-changer for both cancer diagnosis and prognosis strategies. Liquid biopsy tests consider several tumor components, such as DNA, RNA, proteins, and the tiny vesicles originating from tumor cells. Actually, liquid biopsy signifies the genetic alterations of tumors through nucleic acids or cells in various body fluids, including blood, urine, cerebrospinal fluid, or saliva in a noninvasive manner. In this review, we present an overall description of liquid biopsy in which circulating tumor cells, cell-free nucleic acids, exosomes, and extrachromosomal circular DNA are included.

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液体活检:追寻实体瘤基因的独特检测方法。
血液检测是一种液体活检,可检查血液中自由循环的癌细胞或癌细胞核酸。液体活检可用于在早期阶段分辨癌症,它可能会改变癌症诊断和预后策略。液体活检测试考虑了多种肿瘤成分,如 DNA、RNA、蛋白质和来自肿瘤细胞的微小囊泡。实际上,液体活检通过血液、尿液、脑脊液或唾液等各种体液中的核酸或细胞,以非侵入性的方式显示肿瘤的基因改变。在这篇综述中,我们将全面介绍液体活检,其中包括循环肿瘤细胞、无细胞核酸、外泌体和染色体外环状 DNA。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.20
自引率
4.30%
发文量
567
期刊介绍: ACS Applied Electronic Materials is an interdisciplinary journal publishing original research covering all aspects of electronic materials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials science, engineering, optics, physics, and chemistry into important applications of electronic materials. Sample research topics that span the journal's scope are inorganic, organic, ionic and polymeric materials with properties that include conducting, semiconducting, superconducting, insulating, dielectric, magnetic, optoelectronic, piezoelectric, ferroelectric and thermoelectric. Indexed/​Abstracted: Web of Science SCIE Scopus CAS INSPEC Portico
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