AGO2 and its partners: a silencing complex, a chromatin modulator, and new features.

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Critical Reviews in Biochemistry and Molecular Biology Pub Date : 2020-02-01 Epub Date: 2020-03-13 DOI:10.1080/10409238.2020.1738331

Xiaojing Li, Xueying Wang, Zeneng Cheng, Qubo Zhu

引用次数: 38

Abstract

AGO2 is the only member with catalytic activity in Argonaute family and contains four functional core domains, which are N domain, PAZ domain, MID domain, and PIWI domain from N-terminal to C-terminal. In traditional view, AGO2 serves as the catalytic engine of the RNA induced silencing complex and plays an important role in small RNAs guided post transcriptional gene silencing, including mRNA degradation and translational repression. Moreover, AGO2 also plays multiple roles in gene regulation processes in nuclei, such as chromatin remodeling, transcriptional repression and activation, double-strand break repair and alternative splicing. Recent studies have also implicated AGO2 in several other cellular processes, including alternative polyadenylation, translational activation, and transposon repression.

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AGO2及其合作伙伴:沉默复合体、染色质调节剂和新功能。

AGO2是Argonaute家族中唯一具有催化活性的成员，从N端到c端包含4个功能性核心结构域，分别是N结构域、PAZ结构域、MID结构域和PIWI结构域。传统观点认为，AGO2是RNA诱导沉默复合物的催化引擎，在小RNA引导的转录后基因沉默中发挥重要作用，包括mRNA降解和翻译抑制。此外，AGO2还在细胞核内染色质重塑、转录抑制和激活、双链断裂修复和选择性剪接等基因调控过程中发挥多种作用。最近的研究也表明AGO2参与了其他几个细胞过程，包括选择性聚腺苷化、翻译激活和转座子抑制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Biochemistry and Molecular Biology 生物-生化与分子生物学

CiteScore

14.90

自引率

0.00%

发文量

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