Possible therapeutic role of a highly standardized mixture of active compounds derived from cultured Lentinula edodes mycelia (AHCC) in patients infected with 2019 novel coronavirus.

Francesco Di Pierro, Alexander Bertuccioli, Ilaria Cavecchia
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引用次数: 33

Abstract

The outbreak of SARS-CoV-2 disease (COVID-19) is currently, March 2020, affecting more than 100,000 people worldwide and, according to the WHO (World Health Organization), a pandemic is shortly expected. The virus infects the lower respiratory tract and causes severe pneumonia and mortality in approximately 10% and 3-5%, respectively, of cases, mainly among the elderly and/or people affected by other diseases. AHCC is an α-glucan-based standardized mushroom extract that has been extensively investigated as an immunostimulant both in animals and/or in humans affected by West Nile virus, influenza virus, avian influenza virus, hepatitis C virus, papillomavirus, herpes virus, hepatitis B virus and HIV by promoting a regulated and protective immune response. Although the efficacy of AHCC has not yet been specifically evaluated with respect to SARS-CoV-2 disease, its action in promoting a protective response to a wide range of viral infections, and the current absence of effective vaccines, could support its use in the prevention of diseases provoked by human pathogenic coronavirus, including COVID-19.

从培养的香菇菌丝体(AHCC)中提取的高度标准化活性化合物混合物对2019年新型冠状病毒感染患者的可能治疗作用。
SARS-CoV-2疾病(COVID-19)的爆发目前是2020年3月,影响了全球10万多人,据世界卫生组织(WHO)称,预计不久将出现大流行。该病毒感染下呼吸道,分别在大约10%和3-5%的病例中引起严重肺炎和死亡,主要是老年人和/或受其他疾病影响的人。AHCC是一种基于α-葡聚糖的标准化蘑菇提取物,已被广泛研究作为一种免疫兴奋剂,用于动物和/或受西尼罗河病毒、流感病毒、禽流感病毒、丙型肝炎病毒、乳头瘤病毒、疱疹病毒、乙型肝炎病毒和艾滋病毒感染的人类,通过促进受调节和保护性的免疫反应。虽然AHCC对SARS-CoV-2疾病的疗效尚未得到具体评估,但其在促进对广泛病毒感染的保护性反应方面的作用,以及目前缺乏有效疫苗的情况,可能支持将其用于预防由人类致病性冠状病毒引起的疾病,包括COVID-19。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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