A review on Zika virus outbreak, epidemiology, transmission and infection dynamics.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2020-03-04 eCollection Date: 2020-12-01 DOI:10.1186/s40709-020-00115-4

Syeda Sidra Kazmi, Waqar Ali, Nousheen Bibi, Faisal Nouroz

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引用次数: 52

Abstract

Zika virus (ZIKV) is a newly emergent relative of the Flaviviridae family and linked to dengue (DENV) and Chikungunya (CHIVKV). ZIKV is one of the rising pathogens promptly surpassing geographical borders. ZIKV infection was characterized by mild disease with fever, headache, rash, arthralgia and conjunctivitis, with exceptional reports of an association with Guillain-Barre syndrome (GBS) and microcephaly. However, since the end of 2015, an increase in the number of GBS associated cases and an astonishing number of microcephaly in fetus and new-borns in Brazil have been related to ZIKV infection, raising serious worldwide public health concerns. ZIKV is transmitted by the bite of infected female mosquitoes of Aedes species. Clarifying such worrisome relationships is, thus, a current unavoidable goal. Here, we extensively described the current understanding of the effects of ZIKV on heath, clinical manifestation, diagnosis and treatment options based on modern, alternative and complementary medicines regarding the disease.

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寨卡病毒暴发、流行病学、传播和感染动态研究进展

寨卡病毒(ZIKV)是黄病毒科新出现的亲缘病毒，与登革热(DENV)和基孔肯雅热(CHIVKV)有关。寨卡病毒是迅速超越地理边界的新兴病原体之一。寨卡病毒感染的特点是轻微疾病，包括发热、头痛、皮疹、关节痛和结膜炎，特别报道与格林-巴利综合征(GBS)和小头畸形有关。然而，自2015年底以来，巴西GBS相关病例数量的增加以及胎儿和新生儿小头畸形的惊人数量与寨卡病毒感染有关，引起了严重的全球公共卫生问题。寨卡病毒是由受感染的伊蚊雌蚊叮咬传播的。因此，澄清这些令人担忧的关系是当前不可避免的目标。在这里，我们广泛地描述了目前对寨卡病毒对健康的影响、临床表现、基于现代、替代和补充药物的诊断和治疗方案的理解。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.