Thyroid hormones in ovarian follicular fluid: Association with oocyte retrieval in women undergoing assisted fertilization procedures.

IF 1.9

JBRA assisted reproduction Pub Date : 2020-07-14 DOI:10.5935/1518-0557.20200004

Mónica Rosales, Myriam Nuñez, Andrea Abdala, Viviana Mesch, Gabriela Mendeluk

{"title":"Thyroid hormones in ovarian follicular fluid: Association with oocyte retrieval in women undergoing assisted fertilization procedures.","authors":"Mónica Rosales, Myriam Nuñez, Andrea Abdala, Viviana Mesch, Gabriela Mendeluk","doi":"10.5935/1518-0557.20200004","DOIUrl":null,"url":null,"abstract":"Objective: Our aim was to analyze the role of thyroid hormones in follicular fluid (FF) in relation to the number of oocytes retrieved in women recruited for an assisted fertilization procedure.Methods: Retrospective cohort study of 51 women 37.5±3.3 years, range 29-42, evaluated after a controlled ovarian stimulation protocol in a University Hospital. FF was sampled by transvaginal ultrasound-guided aspiration after ovarian hyperstimulation and we measured T3 (T3f), T4 (T4f), TSH (TSHf) and free T4 (T4ff). The oocyte maturation rate was calculated as: Number of metaphase II oocytes/Number of oocytes retrieved x 100. Statistical analysis was performed using the SPSS-19 software.Results: Hormone levels in FF were: TSHf 1.3µIU/ml (0.4 - 2.7), T3f: 1.52±0.46 nmol/L, T4f 88.8±30.9nmol/L and T4ff: 15.44±2.57pmol/L. The number of oocytes recovered was dependent onT4f following the equation: Log (oocyte) = 0.379+0.042*T4f (r:0.352, p=0.012). After a logistic regression model analysis, T3f showed a tendency to be associated with the OMR: OR (95 % CI)= 0.977 (0.954 to 1.001), p=0.057.Conclusions: The correlation found between thyroid hormones and the number of oocytes retrieved suggests an interaction between thyroid and gonadal axes in relation to follicular development.","PeriodicalId":520656,"journal":{"name":"JBRA assisted reproduction","volume":" ","pages":"245-249"},"PeriodicalIF":1.9000,"publicationDate":"2020-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7365548/pdf/","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"JBRA assisted reproduction","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.5935/1518-0557.20200004","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 5

Abstract

Objective: Our aim was to analyze the role of thyroid hormones in follicular fluid (FF) in relation to the number of oocytes retrieved in women recruited for an assisted fertilization procedure.

Methods: Retrospective cohort study of 51 women 37.5±3.3 years, range 29-42, evaluated after a controlled ovarian stimulation protocol in a University Hospital. FF was sampled by transvaginal ultrasound-guided aspiration after ovarian hyperstimulation and we measured T3 (T3f), T4 (T4f), TSH (TSHf) and free T4 (T4ff). The oocyte maturation rate was calculated as: Number of metaphase II oocytes/Number of oocytes retrieved x 100. Statistical analysis was performed using the SPSS-19 software.

Results: Hormone levels in FF were: TSHf 1.3µIU/ml (0.4 - 2.7), T3f: 1.52±0.46 nmol/L, T4f 88.8±30.9nmol/L and T4ff: 15.44±2.57pmol/L. The number of oocytes recovered was dependent onT4f following the equation: Log (oocyte) = 0.379+0.042*T4f (r:0.352, p=0.012). After a logistic regression model analysis, T3f showed a tendency to be associated with the OMR: OR (95 % CI)= 0.977 (0.954 to 1.001), p=0.057.

Conclusions: The correlation found between thyroid hormones and the number of oocytes retrieved suggests an interaction between thyroid and gonadal axes in relation to follicular development.

查看原文本刊更多论文

卵巢卵泡液中的甲状腺激素:与接受辅助受精程序的妇女的卵母细胞回收有关。

目的:我们的目的是分析甲状腺激素在卵泡液(FF)中的作用与辅助受精手术中招募的妇女获得的卵母细胞数量的关系。方法:回顾性队列研究51名37.5±3.3岁，年龄29-42岁的妇女，在大学医院接受卵巢控制刺激方案后进行评估。卵巢过度刺激后经阴道超声引导下抽吸FF，测定T3 (T3f)、T4 (T4f)、TSH (TSHf)和游离T4 (T4ff)。卵母细胞成熟率计算为:中期卵母细胞数/回收卵母细胞数× 100。采用SPSS-19软件进行统计分析。结果:FF中激素水平分别为:TSHf 1.3µIU/ml(0.4 ~ 2.7)、T3f 1.52±0.46 nmol/L、T4f 88.8±30.9nmol/L、T4ff 15.44±2.57pmol/L。恢复的卵母细胞数依赖于onT4f，公式为:Log(卵母细胞)= 0.379+0.042*T4f (r:0.352, p=0.012)。经logistic回归模型分析，T3f与OMR有相关性:OR (95% CI)= 0.977 (0.954 ~ 1.001)， p=0.057。结论:甲状腺激素与卵母细胞数量之间的相关性表明，甲状腺轴和性腺轴在卵泡发育中存在相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

JBRA assisted reproduction

自引率

0.00%

发文量