Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population.

IF 3.4 Q2 BIOCHEMICAL RESEARCH METHODS

Biochemistry Research International Pub Date : 2020-02-17 eCollection Date: 2020-01-01 DOI:10.1155/2020/9589310

Ning Wang, Boshen Wang, Jiadi Guo, Suhao Zhang, Lei Han, Juan Zhang, Baoli Zhu

{"title":"Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population.","authors":"Ning Wang, Boshen Wang, Jiadi Guo, Suhao Zhang, Lei Han, Juan Zhang, Baoli Zhu","doi":"10.1155/2020/9589310","DOIUrl":null,"url":null,"abstract":"Objectives: The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.Methods: We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.Results: We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5. Conclusion. The genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.","PeriodicalId":8826,"journal":{"name":"Biochemistry Research International","volume":"2020 ","pages":"9589310"},"PeriodicalIF":3.4000,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/9589310","citationCount":"4","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biochemistry Research International","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1155/2020/9589310","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2020/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}

引用次数: 4

Abstract

Objectives: The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3'UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

Methods: We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

Results: We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5. Conclusion. The genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on.

Abstract Image

查看原文本刊更多论文

中国人群中XPO5基因单核苷酸多态性与噪声性听力损失有关

目的:本研究旨在探讨XPO5基因3′utr单核苷酸多态性(SNP)与噪声性听力损失(NIHL)发生的相关性，并进一步探讨NIHL中miRNAs对XPO5基因与噪声性听力损失(NIHL)发生的调控机制，进一步探讨miRNAs对NIHL的调控机制。方法:采用病例-对照研究，纳入1040例病例和1060例对照。研究snp对XPO5基因与噪声性听力损失(NIHL)发生的影响，并进一步探讨NIHL中mirna对其的调控机制。结果:我们对XPO5基因中4个snp (rs2257082、rs11077、rs7755135、rs1106841)与噪声性听力损失(NIHL)的发生进行基因分型，进一步探讨NIHL中miRNAs对XPO5基因与噪声性听力损失(NIHL)发生的调控机制，并进一步探讨NIHL中miRNAs对XPO5基因与噪声性听力损失(NIHL)发生的调控机制，进一步探讨NIHL中miRNAs对XPO5基因与噪声性听力损失(NIHL)发生的调控机制，进一步探讨NIHL中miRNAs对XPO5基因与噪声性听力损失(NIHL)发生的调控机制。结论。在中国人群中，XPO5基因的遗传多态性rs11077与噪声性听力损失的风险相关。XPO5基因与噪声性听力损失(NIHL)发生的关系，并进一步探讨mirna在NIHL中的调控机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊