Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery.

IF 9.6 1区化学 Q1 MATERIALS SCIENCE, MULTIDISCIPLINARY

ACS Materials Letters Pub Date : 2020-03-05 DOI:10.1016/j.stem.2020.02.011

Arun Sharma, Samuel Sances, Michael J Workman, Clive N Svendsen

引用次数: 0

Abstract

Human induced pluripotent stem cells (hiPSCs) provide a powerful platform for disease modeling and have unlocked new possibilities for understanding the mechanisms governing human biology, physiology, and genetics. However, hiPSC-derivatives have traditionally been utilized in two-dimensional monocultures, in contrast to the multi-systemic interactions that influence cells in the body. We will discuss recent advances in generating more complex hiPSC-based systems using three-dimensional organoids, tissue-engineering, microfluidic organ-chips, and humanized animal systems. While hiPSC differentiation still requires optimization, these next-generation multi-lineage technologies can augment the biomedical researcher's toolkit and enable more realistic models of human tissue function.

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用于疾病建模和药物发现的多系人类 iPSC 衍生平台。

人类诱导多能干细胞（hiPSCs）为疾病建模提供了一个强大的平台，并为了解人类生物学、生理学和遗传学机制提供了新的可能性。然而，hiPSC 衍生物传统上都是在二维单培养基中使用，这与影响体内细胞的多系统相互作用形成了鲜明对比。我们将讨论利用三维器官组织、组织工程、微流体器官芯片和人源化动物系统生成更复杂的基于 hiPSC 的系统的最新进展。虽然 hiPSC 分化仍需优化，但这些下一代多系技术可以增强生物医学研究人员的工具包，并实现更逼真的人体组织功能模型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Materials Letters MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

14.60

自引率

3.50%

发文量

261

期刊介绍： ACS Materials Letters is a journal that publishes high-quality and urgent papers at the forefront of fundamental and applied research in the field of materials science. It aims to bridge the gap between materials and other disciplines such as chemistry, engineering, and biology. The journal encourages multidisciplinary and innovative research that addresses global challenges. Papers submitted to ACS Materials Letters should clearly demonstrate the need for rapid disclosure of key results. The journal is interested in various areas including the design, synthesis, characterization, and evaluation of emerging materials, understanding the relationships between structure, property, and performance, as well as developing materials for applications in energy, environment, biomedical, electronics, and catalysis. The journal has a 2-year impact factor of 11.4 and is dedicated to publishing transformative materials research with fast processing times. The editors and staff of ACS Materials Letters actively participate in major scientific conferences and engage closely with readers and authors. The journal also maintains an active presence on social media to provide authors with greater visibility.