Modeling immune cell behavior across scales in cancer.

IF 7.9 Q1 Medicine
Sahak Z Makaryan, Colin G Cess, Stacey D Finley
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引用次数: 25

Abstract

Detailed, mechanistic models of immune cell behavior across multiple scales in the context of cancer provide clinically relevant insights needed to understand existing immunotherapies and develop more optimal treatment strategies. We highlight mechanistic models of immune cells and their ability to become activated and promote tumor cell killing. These models capture various aspects of immune cells: (a) single-cell behavior by predicting the dynamics of intracellular signaling networks in individual immune cells, (b) multicellular interactions between tumor and immune cells, and (c) multiscale dynamics across space and different levels of biological organization. Computational modeling is shown to provide detailed quantitative insight into immune cell behavior and immunotherapeutic strategies. However, there are gaps in the literature, and we suggest areas where additional modeling efforts should be focused to more prominently impact our understanding of the complexities of the immune system in the context of cancer. This article is categorized under: Biological Mechanisms > Cell Signaling Models of Systems Properties and Processes > Mechanistic Models Models of Systems Properties and Processes > Cellular Models.

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在癌症中模拟免疫细胞的行为。
在癌症背景下,跨多个尺度的免疫细胞行为的详细机制模型提供了了解现有免疫疗法和制定更优化治疗策略所需的临床相关见解。我们强调免疫细胞的机制模型及其激活和促进肿瘤细胞杀伤的能力。这些模型捕捉了免疫细胞的各个方面:(a)通过预测个体免疫细胞中细胞内信号网络的动力学来实现单细胞行为,(b)肿瘤和免疫细胞之间的多细胞相互作用,以及(c)跨空间和不同生物组织水平的多尺度动力学。计算模型显示提供详细的定量洞察免疫细胞行为和免疫治疗策略。然而,文献中存在空白,我们建议应该关注额外建模工作的领域,以更显着地影响我们对癌症背景下免疫系统复杂性的理解。本文分类如下:生物学机制>系统特性和过程的细胞信号传导模型>系统特性和过程的机制模型>细胞模型。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
18.40
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Journal Name:Wiley Interdisciplinary Reviews-Systems Biology and Medicine Focus: Strong interdisciplinary focus Serves as an encyclopedic reference for systems biology research Conceptual Framework: Systems biology asserts the study of organisms as hierarchical systems or networks Individual biological components interact in complex ways within these systems Article Coverage: Discusses biology, methods, and models Spans systems from a few molecules to whole species Topical Coverage: Developmental Biology Physiology Biological Mechanisms Models of Systems, Properties, and Processes Laboratory Methods and Technologies Translational, Genomic, and Systems Medicine
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