Endogenous Opioids at the Intersection of Opioid Addiction, Pain, and Depression: The Search for a Precision Medicine Approach.

IF 12.1 1区 医学 Q1 NEUROSCIENCES
Annual review of neuroscience Pub Date : 2020-07-08 Epub Date: 2020-02-28 DOI:10.1146/annurev-neuro-110719-095912
Michael A Emery, Huda Akil
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引用次数: 0

Abstract

Opioid addiction and overdose are at record levels in the United States. This is driven, in part, by their widespread prescription for the treatment of pain, which also increased opportunity for diversion by sensation-seeking users. Despite considerable research on the neurobiology of addiction, treatment options for opioid abuse remain limited. Mood disorders, particularly depression, are often comorbid with both pain disorders and opioid abuse. The endogenous opioid system, a complex neuromodulatory system, sits at the neurobiological convergence point of these three comorbid disease states. We review evidence for dysregulation of the endogenous opioid system as a mechanism for the development of opioid addiction and/or mood disorder. Specifically, individual differences in opioid system function may underlie differences in vulnerability to opioid addiction and mood disorders. We also review novel research, which promises to provide more detailed understanding of individual differences in endogenous opioid neurobiology and its contribution to opioid addiction susceptibility.

阿片类药物成瘾、疼痛和抑郁交汇处的内源性阿片类药物:寻找精准医学方法》。
在美国,阿片类药物成瘾和用药过量达到了创纪录的水平。造成这一现象的部分原因是,阿片类药物被广泛用于治疗疼痛,这也增加了寻求感觉的使用者转移药物的机会。尽管对成瘾的神经生物学进行了大量研究,但阿片类药物滥用的治疗方案仍然有限。情绪障碍,尤其是抑郁症,往往与疼痛障碍和阿片类药物滥用同时存在。内源性阿片系统是一个复杂的神经调节系统,位于这三种并发症的神经生物学汇合点。我们回顾了内源性阿片系统失调作为阿片类药物成瘾和/或情绪障碍发展机制的证据。具体而言,阿片系统功能的个体差异可能是阿片类药物成瘾和情绪障碍易感性差异的基础。我们还回顾了一些新的研究,这些研究有望让人们更详细地了解内源性阿片神经生物学的个体差异及其对阿片类药物成瘾易感性的影响。
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来源期刊
Annual review of neuroscience
Annual review of neuroscience 医学-神经科学
CiteScore
25.30
自引率
0.70%
发文量
29
期刊介绍: The Annual Review of Neuroscience is a well-established and comprehensive journal in the field of neuroscience, with a rich history and a commitment to open access and scholarly communication. The journal has been in publication since 1978, providing a long-standing source of authoritative reviews in neuroscience. The Annual Review of Neuroscience encompasses a wide range of topics within neuroscience, including but not limited to: Molecular and cellular neuroscience, Neurogenetics, Developmental neuroscience, Neural plasticity and repair, Systems neuroscience, Cognitive neuroscience, Behavioral neuroscience, Neurobiology of disease. Occasionally, the journal also features reviews on the history of neuroscience and ethical considerations within the field.
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