Correlation between Urine N-Terminal Telopeptide and Fourier Transform Infrared Spectroscopy Parameters: A Preliminary Study.

IF 1.1 Q3 ORTHOPEDICS
Journal of Osteoporosis Pub Date : 2020-02-11 eCollection Date: 2020-01-01 DOI:10.1155/2020/5725086
Ichiro Okano, Stephan N Salzmann, Courtney Ortiz Miller, Colleen Rentenberger, Paul Schadler, Oliver C Sax, Jennifer Shue, Andrew A Sama, Frank P Cammisa, Federico P Girardi, Alexander P Hughes
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引用次数: 4

Abstract

N-terminal telopeptide (NTX) is a bone resorption marker that is commonly referenced in clinical practice. Bone remodeling is also associated with changes in mineral components. Fourier transform infrared spectroscopy (FTIR) is utilized in the assessment of bone material properties and some parameters are reported to have associations with bone remodeling. The aim of this cross-sectional study is to investigate the relationship between uNTX levels and FTIR parameters, utilizing prospectively collected study data for patients who underwent lumbar fusion surgery. Bone specimens were taken from iliac crest (IC) and vertebrae (V). Cortical (C) and trabecular (T) bones were separately analyzed. 22 patients (mean age 60.0 years (35.9-73.3), male : female 9 : 13) were included in the final analysis. Women showed significantly higher uNTX levels (male : female, median [range] 21.0 [11.0-39.0] : 36.0 [15.0-74.0] nM·BCE/mM, p=0.033). Among women, a significant positive correlation was observed between uNTX and mineral-to-matrix ratio in IC-C. Among men, uNTX demonstrated significant negative correlation with collagen crosslinks (XLR: ratio of mature to immature collagen crosslinks) in IC-C, V-T, and V-C. In addition, uNTX was positively correlated with acid phosphate substitution (HPO4, a parameter of new bone formation) in IC-C, IC-T, and V-C. After age adjustment, HPO4 in IC-T and V-C among men showed significant positive associations with uNTX (IC-T: p=0.018, R 2 = 0.544; V-C: p=0.007, R 2 = 0.672). We found associations between FTIR parameters and uNTX in men, but not in women. The correlations between uNTX and FTIR parameters in men might suggest a better balance of bone breakdown (uNTX) and new bone formation (FTIR parameters: XLR, HPO4) than in women.

Abstract Image

尿n端末端肽与傅里叶变换红外光谱参数相关性的初步研究。
n端末端肽(NTX)是临床常用的骨吸收标志物。骨重塑也与矿物质成分的变化有关。傅里叶变换红外光谱(FTIR)被用于骨材料性能的评估,据报道,一些参数与骨重塑有关。本横断面研究的目的是利用前瞻性收集的腰椎融合手术患者的研究数据,探讨uNTX水平与FTIR参数之间的关系。骨标本取自髂骨(IC)和椎骨(V)。皮质骨(C)和骨小梁(T)分别进行分析。最终纳入22例患者,平均年龄60.0岁(35.9 ~ 73.3岁),男女比例为9.13。女性的uNTX水平显著高于男性(男性:女性,中位数[范围]21.0 [11.0-39.0]:36.0 [15.0-74.0]nM·BCE/mM, p=0.033)。在女性中,uNTX与IC-C中矿物质-基质比之间存在显著的正相关。在男性中,uNTX与IC-C、V-T和V-C的胶原交联(XLR:成熟与未成熟胶原交联的比率)呈显著负相关。此外,在IC-C、IC-T和V-C中,uNTX与酸性磷酸盐取代(HPO4,新骨形成的一个参数)呈正相关。年龄调整后,男性IC-T和V-C的HPO4与uNTX呈显著正相关(IC-T: p=0.018, r2 = 0.544;V-C: p=0.007, r2 = 0.672)。我们发现FTIR参数和uNTX在男性中存在关联,但在女性中没有。男性的uNTX和FTIR参数之间的相关性可能表明,与女性相比,男性在骨分解(uNTX)和新骨形成(FTIR参数:XLR, HPO4)方面的平衡更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
0.00%
发文量
6
审稿时长
20 weeks
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