Chaperonin-assisted protein folding: a chronologue.

IF 7.2 2区 生物学 Q1 BIOPHYSICS
Arthur L Horwich, Wayne A Fenton
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引用次数: 24

Abstract

This chronologue seeks to document the discovery and development of an understanding of oligomeric ring protein assemblies known as chaperonins that assist protein folding in the cell. It provides detail regarding genetic, physiologic, biochemical, and biophysical studies of these ATP-utilizing machines from both in vivo and in vitro observations. The chronologue is organized into various topics of physiology and mechanism, for each of which a chronologic order is generally followed. The text is liberally illustrated to provide firsthand inspection of the key pieces of experimental data that propelled this field. Because of the length and depth of this piece, the use of the outline as a guide for selected reading is encouraged, but it should also be of help in pursuing the text in direct order.

伴侣蛋白辅助的蛋白质折叠:年表。
本编年史旨在记录对寡聚环蛋白组装的理解的发现和发展,称为伴侣蛋白,协助细胞中的蛋白质折叠。它提供了关于这些atp利用机器在体内和体外观察的遗传、生理、生化和生物物理研究的细节。编年史分为生理学和机制的不同主题,每个主题通常遵循时间顺序。文本是自由说明,以提供第一手检查的关键部分的实验数据,推动这一领域。由于这篇文章的长度和深度,我们鼓励使用提纲作为选择阅读的指南,但它也应该有助于按照直接顺序阅读文本。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Quarterly Reviews of Biophysics
Quarterly Reviews of Biophysics 生物-生物物理
CiteScore
12.90
自引率
1.60%
发文量
16
期刊介绍: Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.
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