A Pilot Study of FDG-PET/CT in Polycythemia Vera Using Global Analysis Techniques.

Q3 Medicine

Asia Oceania Journal of Nuclear Medicine and Biology Pub Date : 2020-01-01 DOI:10.22038/aojnmb.2019.41192.1278

Cyrus Ayubcha, Hitomi Hosoya, Siavash Mehdizadeh Seraj, Mahdi Zirakchian Zadeh, Thomas Werner M S E, Abass Alavi

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引用次数: 2

Abstract

Objectives: Functional imaging presents a non-invasive process that may capture the hyper-metabolic nature of red bone marrow in myeloproliferative neoplasms, such as polycythemia vera (PV).

Methods: This study analyzed the FDG-PET/CT scans (n=12) of six patients diagnosed with PV and six age-sex matched controls using a quantitative global analysis methodology.

Results: All PV patients had elevated activities in the bone marrow of each skeletal structure as compared to matched controls with respect to mean standardized uptake value (femoral neck p=0.01, lumbar spine p=0.02, pelvis p=0.002, sternum p=0.04). Notable variations in splenic uptake were observed among the treated and untreated PV patients.

Conclusion: Our study exemplifies the potential utility of PET in reflecting hyperactive bone marrow activity related to PV. Future studies may further substantiate and elaborate on the use of PET-derived metabolic data in PV.

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FDG-PET/CT对真性红细胞增多症的初步研究。

目的:功能成像提供了一种非侵入性的方法，可以捕捉骨髓增殖性肿瘤(如真性红细胞增多症(PV))中红骨髓的高代谢特性。方法:本研究采用定量全局分析方法，分析了6例确诊为PV的患者(n=12)和6例年龄性别匹配的对照组的FDG-PET/CT扫描结果。结果:与对照组相比，所有PV患者的骨髓中各骨骼结构的平均标准化摄取值均升高(股骨颈p=0.01，腰椎p=0.02，骨盆p=0.002，胸骨p=0.04)。在治疗和未治疗的PV患者中观察到脾脏摄取的显著变化。结论:我们的研究证明了PET在反映PV相关的骨髓活性亢进方面的潜在效用。未来的研究可能会进一步证实和阐述pet衍生的代谢数据在PV中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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