Extracellular Vesicles in Epstein-Barr Virus Pathogenesis.

IF 3.1 Q2 MICROBIOLOGY

Current Clinical Microbiology Reports Pub Date : 2019-09-01 Epub Date: 2019-07-03 DOI:10.1007/s40588-019-00123-6

Allaura S Cone, Sara B York, David G Meckes

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引用次数: 15

Abstract

Purpose of review: Epstein-Barr virus (EBV) is a known determinant for numerous malignancies and may contribute to autoimmune diseases. The underlining mechanisms behind EBV pathologies is not completely understood. Recently, extracellular vesicles (EVs) released from infected cells have been found to produce profound effects on cellular microenvironments. Therefore, in this review we sought to critically evaluate the roles of EVs in EBV pathogenesis and assess their potential therapeutic and diagnostic utility.

Recent findings: EBV-altered EVs are capable of activating signaling cascades and phenotypic changes in recipient cells through the transfer of viral proteins and RNAs. Moreover, several EV-associated microRNAs have encouraging prognostic or diagnostic potential in EBV-associated cancers.

Summary: Current evidence suggests that EBV-modified EVs affect viral pathogenesis and cancer progression. However, further research is needed to investigate the direct role of both viral and host products on recipient cells and the mechanisms driving viral protein and RNA EV packaging and content modification.

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eb病毒发病机制中的细胞外囊泡

综述目的:eb病毒(EBV)是许多恶性肿瘤的已知决定因素，并可能导致自身免疫性疾病。EBV病理背后的主要机制尚不完全清楚。近年来，从感染细胞中释放的细胞外囊泡(EVs)被发现对细胞微环境产生深远的影响。因此，在这篇综述中，我们试图批判性地评估ev在EBV发病机制中的作用，并评估其潜在的治疗和诊断价值。最近发现:ebv改变的ev能够通过病毒蛋白和rna的转移激活受体细胞的信号级联反应和表型变化。此外，一些与ebv相关的microrna在ebv相关的癌症中具有令人鼓舞的预后或诊断潜力。摘要:目前的证据表明，ebv修饰的ev影响病毒的发病机制和癌症的进展。然而，需要进一步研究病毒和宿主产物在受体细胞上的直接作用，以及驱动病毒蛋白和RNA EV包装和内容修饰的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Clinical Microbiology Reports MICROBIOLOGY-

CiteScore

7.50

自引率

1.90%

发文量

期刊介绍： Current Clinical Microbiology Reports commissions expert reviews from leading scientists at the forefront of research in microbiology. The journal covers this broad field by dividing it into four key main areas of study: virology, bacteriology, parasitology, and mycology. Within each of the four sections, experts from around the world address important aspects of clinical microbiology such as immunology, diagnostics, therapeutics, antibiotics and antibiotic resistance, and vaccines. Some of the world’s foremost authorities in the field of microbiology serve as section editors and editorial board members. Section editors select topics for which leading researchers are invited to contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, which are highlighted in annotated reference lists. These timely reviews of the literature examine the latest scientific discoveries and controversies as they emerge and are indispensable to both researchers and clinicians. The editorial board, composed of more than 20 internationally diverse members, reviews the annual table of contents, ensures that topics address all aspects of emerging research, and where applicable suggests topics of critical importance to various countries/regions.

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