Rapid detection of urokinase plasminogen activator using flexible paper-based graphene-gold platform.

IF 2.1 4区医学 Q2 Physics and Astronomy

Biointerphases Pub Date : 2020-02-04 DOI:10.1116/1.5128889

Bipin Sharma, Prakash Parajuli, Ramakrishna Podila

引用次数: 0

Abstract

Many studies have shown that urokinase plasminogen activator (uPA) is causally involved in promoting cancer invasion and metastasis. Thus, monitoring uPA levels could be very useful in cancer diagnosis, identification of initial metastasis, and guiding cancer treatment. Here, the authors developed a novel and scalable uPA sensor based on a graphene-gold nanoparticle platform that uses fluorescence of quantum dots to rapidly (<1 h) detect uPA up to 100 pM. Indeed, the authors' sensor is highly selective and showed an ability to sense up to 100 pM uPA even in the presence of complex biological milieu such as the fetal bovine serum.

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柔性纸基石墨烯-金平台快速检测尿激酶纤溶酶原激活剂。

许多研究表明，尿激酶纤溶酶原激活物(uPA)在促进肿瘤侵袭和转移中起着因果关系。因此，监测uPA水平在癌症诊断、早期转移的识别和指导癌症治疗方面非常有用。在这里，作者开发了一种基于石墨烯-金纳米粒子平台的新型可扩展uPA传感器，该传感器利用量子点的荧光快速(

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biointerphases BIOPHYSICS-MATERIALS SCIENCE, BIOMATERIALS

CiteScore

4.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Biointerphases emphasizes quantitative characterization of biomaterials and biological interfaces. As an interdisciplinary journal, a strong foundation of chemistry, physics, biology, engineering, theory, and/or modelling is incorporated into originated articles, reviews, and opinionated essays. In addition to regular submissions, the journal regularly features In Focus sections, targeted on specific topics and edited by experts in the field. Biointerphases is an international journal with excellence in scientific peer-review. Biointerphases is indexed in PubMed and the Science Citation Index (Clarivate Analytics). Accepted papers appear online immediately after proof processing and are uploaded to key citation sources daily. The journal is based on a mixed subscription and open-access model: Typically, authors can publish without any page charges but if the authors wish to publish open access, they can do so for a modest fee. Topics include: bio-surface modification nano-bio interface protein-surface interactions cell-surface interactions in vivo and in vitro systems biofilms / biofouling biosensors / biodiagnostics bio on a chip coatings interface spectroscopy biotribology / biorheology molecular recognition ambient diagnostic methods interface modelling adhesion phenomena.