Successful Treatment for Hypercalcemia due to Cosecretion of Parathyroid Hormone-Related Protein and 1,25-Dihydroxyvitamin D3 in Non-Small-Cell Lung Cancer: A Case Report and Literature Review.

Q4 Medicine
Case Reports in Pulmonology Pub Date : 2020-01-03 eCollection Date: 2020-01-01 DOI:10.1155/2020/2475725
Takunori Ogawa, Jun Miyata, Koichi Fukunaga, Akihiko Kawana, Takashi Inoue
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引用次数: 6

Abstract

Hypercalcemia of malignancy frequently manifests as paraneoplastic syndrome in patients with solid tumors. A 71-year-old man was diagnosed with stage IIIB lung squamous cell carcinoma. Laboratory examination revealed high serum calcium concentration with elevated serum parathyroid hormone-related protein (PTHrP) and 1,25-dihydroxyvitamin D3 levels. As the patient did not respond to the initial treatment with calcitonin, extracellular fluid infusion, and chemotherapy, systemic prednisolone was administered additionally. Thus, the levels of serum calcium normalized and PTHrP and 1,25-dihydroxyvitamin D3 decreased simultaneously. To our knowledge, this is the first case report on the successful treatment of hypercalcemia of malignancy caused by PTHrP and 1,25-dihydroxyvitamin D3 cosecretion in a patient with lung cancer.

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非小细胞肺癌中甲状旁腺激素相关蛋白和1,25-二羟基维生素D3共同分泌导致的高钙血症的成功治疗:1例报告和文献综述
恶性肿瘤高钙血症常表现为实体瘤患者的副肿瘤综合征。一位71岁的男性被诊断为IIIB期肺鳞状细胞癌。实验室检查显示血清钙浓度高,血清甲状旁腺激素相关蛋白(PTHrP)和1,25-二羟基维生素D3水平升高。由于患者对降钙素、细胞外液输注和化疗的初始治疗无反应,因此额外给予全身强的松龙治疗。因此,血清钙水平正常化,PTHrP和1,25-二羟基维生素D3水平同时下降。据我们所知,这是第一例成功治疗肺癌患者PTHrP和1,25-二羟基维生素D3共同分泌引起的恶性肿瘤高钙血症的病例报告。
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来源期刊
Case Reports in Pulmonology
Case Reports in Pulmonology Medicine-Pulmonary and Respiratory Medicine
CiteScore
1.80
自引率
0.00%
发文量
23
审稿时长
13 weeks
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