Genetic and epigenetic editing in
nervous system
.

IF 8.3 2区 医学 Q1 Medicine
Jeremy J Day
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引用次数: 5

Abstract

Numerous neuronal functions depend on the precise spatiotemporal regulation of gene expression, and the cellular machinery that contributes to this regulation is frequently disrupted in neurodevelopmental, neuropsychiatric, and neurological disease states. Recent advances in gene editing technology have enabled increasingly rapid understanding of gene sequence variation and gene regulatory function in the central nervous system. Moreover, these tools have provided new insights into the locus-specific functions of epigenetic modifications and enabled epigenetic editing at specific gene loci in disease contexts. Continued development of clustered regularly interspaced short palindromic repeats (CRISPR)-based tools has provided not only cell-specific modulation, but also rapid induction profiles that permit sophisticated interrogation of the temporal dynamics that contribute to brain health and disease. This review summarizes recent advances in genetic editing, transcriptional modulation, and epigenetic reorganization, with a focus on applications to neuronal systems and potential uses in brain disorders characterized by genetic sequence variation or transcriptional dysregulation.
.

Abstract Image

Abstract Image

神经系统
的遗传和表观遗传编辑。
许多神经元功能依赖于基因表达的精确时空调控,而参与这种调控的细胞机制在神经发育、神经精神和神经疾病状态下经常被破坏。近年来,随着基因编辑技术的进步,人们对中枢神经系统基因序列变异和基因调控功能的了解越来越快。此外,这些工具为表观遗传修饰的位点特异性功能提供了新的见解,并使疾病背景下特定基因位点的表观遗传编辑成为可能。基于聚集规律间隔短回文重复序列(CRISPR)的工具的持续发展不仅提供了细胞特异性调节,而且还提供了快速诱导谱,允许对有助于大脑健康和疾病的时间动态进行复杂的询问。本文综述了基因编辑、转录调节和表观遗传重组的最新进展,重点介绍了基因编辑在神经系统中的应用以及在以基因序列变异或转录失调为特征的脑部疾病中的潜在应用。
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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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