Epigenetics as a key link between psychosocial stress and aging: concepts, evidence, mechanisms
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IF 8.3 2区 医学 Q1 Medicine
Anthony S Zannas
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引用次数: 23

Abstract

Psychosocial stress-especially when chronic, excessive, or occurring early in life-has been associated with accelerated aging and increased disease risk. With rapid aging of the world population, the need to elucidate the underlying mechanisms is pressing, now more so than ever. Among molecular mechanisms linking stress and aging, the present article reviews evidence on the role of epigenetics, biochemical processes that can be set into motion by stressors and in turn influence genomic function and complex phenotypes, including aging-related outcomes. The article further provides a conceptual mechanistic framework on how stress may drive epigenetic changes at susceptible genomic sites, thereby exerting systems-level effects on the aging epigenome while also regulating the expression of molecules implicated in aging-related processes. This emerging evidence, together with work examining related biological processes, begins to shed light on the epigenetic and, more broadly, molecular underpinnings of the long-hypothesized connection between stress and aging.
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Abstract Image

Abstract Image

表观遗传学作为社会心理压力和衰老之间的关键联系:概念,证据,机制
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心理社会压力——尤其是慢性的、过度的或在生命早期发生时——与加速衰老和增加疾病风险有关。随着世界人口的迅速老龄化,现在比以往任何时候都更迫切需要阐明潜在的机制。在连接应激和衰老的分子机制中,本文回顾了表观遗传学、生化过程的作用,这些过程可以由应激源启动,进而影响基因组功能和复杂表型,包括衰老相关的结果。这篇文章进一步提供了一个概念性的机制框架,说明压力如何驱动易感基因组位点的表观遗传变化,从而对衰老表观基因组施加系统水平的影响,同时也调节与衰老相关过程有关的分子的表达。这些新出现的证据,加上对相关生物过程的研究,开始揭示长期假设的压力和衰老之间联系的表观遗传学和更广泛的分子基础。
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来源期刊
Dialogues in Clinical Neuroscience
Dialogues in Clinical Neuroscience Medicine-Psychiatry and Mental Health
CiteScore
19.30
自引率
1.20%
发文量
1
期刊介绍: Dialogues in Clinical Neuroscience (DCNS) endeavors to bridge the gap between clinical neuropsychiatry and the neurosciences by offering state-of-the-art information and original insights into pertinent clinical, biological, and therapeutic aspects. As an open access journal, DCNS ensures accessibility to its content for all interested parties. Each issue is curated to include expert reviews, original articles, and brief reports, carefully selected to offer a comprehensive understanding of the evolving landscape in clinical neuroscience. Join us in advancing knowledge and fostering dialogue in this dynamic field.
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