Intermittent Hypoxia Training for Treating Mild Cognitive Impairment: A Pilot Study.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

American Journal of Alzheimers Disease and Other Dementias Pub Date : 2020-01-01 DOI:10.1177/1533317519896725

Hong Wang, Xiangrong Shi, Hannah Schenck, James R Hall, Sarah E Ross, Geoffrey P Kline, Shande Chen, Robert T Mallet, Peijie Chen

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Abstract

Although intermittent hypoxia training (IHT) has proven effective against various clinical disorders, its impact on mild cognitive impairment (MCI) is unknown. This pilot study examined IHT's safety and therapeutic efficacy in elderly patients with amnestic MCI (aMCI). Seven patients with aMCI (age 69 ± 3 years) alternately breathed 10% O₂ and room-air, each 5 minutes, for 8 cycles/session, 3 sessions/wk for 8 weeks. The patients' resting arterial pressures fell by 5 to 7 mm Hg (P < .05) and cerebral tissue oxygenation increased (P < .05) following IHT. Intermittent hypoxia training enhanced hypoxemia-induced cerebral vasodilation (P < .05) and improved mini-mental state examination and digit span scores from 25.7 ± 0.4 to 27.7 ± 0.6 (P = .038) and from 24.7 ± 1.2 to 26.1 ± 1.3 (P = .047), respectively. California verbal learning test score tended to increase (P = .102), but trail making test-B and controlled oral word association test scores were unchanged. Adaptation to moderate IHT may enhance cerebral oxygenation and hypoxia-induced cerebrovasodilation while improving short-term memory and attention in elderly patients with aMCI.

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治疗轻度认知障碍的间歇性低氧训练：试点研究。

尽管间歇性缺氧训练（IHT）已被证明对多种临床疾病有效，但其对轻度认知障碍（MCI）的影响尚不清楚。这项试验性研究考察了间歇缺氧训练在老年失忆性 MCI（aMCI）患者中的安全性和疗效。七名 MCI 患者（年龄为 69 ± 3 岁）交替呼吸 10% 的氧气和室内空气，每次 5 分钟，每次 8 个周期，每周 3 次，共持续 8 周。间歇缺氧训练后，患者的静息动脉压下降了 5 到 7 毫米汞柱（P < .05），脑组织氧合增加（P < .05）。间歇性缺氧训练增强了低氧血症诱导的脑血管扩张（P < .05），并提高了迷你精神状态检查和数字跨度得分，分别从 25.7 ± 0.4 分提高到 27.7 ± 0.6 分（P = .038）和从 24.7 ± 1.2 分提高到 26.1 ± 1.3 分（P = .047）。加利福尼亚言语学习测试的得分有上升趋势（P = .102），但线索制作测试-B 和控制性口语单词联想测试的得分没有变化。适应中度 IHT 可增强大脑缺氧和缺氧引起的脑血管舒张，同时改善老年肌肉萎缩症患者的短期记忆和注意力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Alzheimers Disease and Other Dementias GERIATRICS & GERONTOLOGY-CLINICAL NEUROLOGY

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： American Journal of Alzheimer''s Disease and other Dementias® (AJADD) is for professionals on the frontlines of Alzheimer''s care, dementia, and clinical depression--especially physicians, nurses, psychiatrists, administrators, and other healthcare specialists who manage patients with dementias and their families. This journal is a member of the Committee on Publication Ethics (COPE).