Plasma luteinizing hormone level affects the brain activity of patients with polycystic ovary syndrome

IF 3.4 2区医学 Q2 ENDOCRINOLOGY & METABOLISM

Psychoneuroendocrinology Pub Date : 2020-02-01 DOI:10.1016/j.psyneuen.2019.104535

Wanlin Lai , Xuan Li , Huili Zhu , Xi Zhu , Huiwen Tan , Peimin Feng , Lei Chen , Cheng Luo

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引用次数: 10

Abstract

Objective

Cognitive function has been reported to be impaired in women with polycystic ovary syndrome (PCOS). This study aimed to investigate the effect of PCOS on brain activity and explore the relationship between brain activity and sex hormone levels in women with PCOS (WPCOS).

Methods

Twenty-one women aged 18–45 years old with new-diagnosed PCOS were enrolled. Plasma levels of six sex hormones including luteinizing hormone (LH) and follicle-stimulating hormone (FSH) were tested during the 2–5 days of their menstrual periods. Twenty-seven healthy controls (HC) were recruited. Every subject underwent a resting-state functional magnetic resonance imaging (fMRI). The amplitude of low-frequency fluctuation (ALFF) of the whole brain was evaluated followed by the functional connectivity (FC) analysis. Finally, the correlation between the ALFF, FC of the significant areas and the plasma hormone levels were analyzed.

Results

The patients showed increased ALFF value in the left inferior temporal gyrus (ITG.L) and decreased ALFF value in the left inferior occipital gyrus (IOG.L) as well as the superior frontal gyrus (SFG.R, P < 0.005). For the FC analysis, patients showed decreased FC in SFG.R with the right middle frontal gyrus (MFG.R, P < 0.05). The FC between SFG.R and MFG.R was negatively correlated with LH level (R=-0.594, P = 0.005) and with the LH/FSH ratio (R=-0.521, P = 0.015).

Conclusion

PCOS can induce changes in activities of brain regions responsible for visuospatial working memory, face processing and episodic memory. The reduced functional connectivity within the right frontal lobe is related with the high LH level in WPCOS.

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血浆黄体生成素水平影响多囊卵巢综合征患者的脑活动

目的多囊卵巢综合征(PCOS)患者认知功能受损。本研究旨在探讨多囊卵巢综合征(PCOS)对大脑活动的影响，并探讨多囊卵巢综合征(WPCOS)女性大脑活动与性激素水平的关系。方法选取21名年龄在18-45岁的新诊断PCOS的女性。在月经周期的2-5天内检测6种性激素的血浆水平，包括黄体生成素(LH)和卵泡刺激素(FSH)。招募27名健康对照(HC)。每个受试者进行静息状态功能磁共振成像(fMRI)。测定全脑低频波动幅度(ALFF)，并进行功能连通性(FC)分析。最后分析显著区ALFF、FC与血浆激素水平的相关性。结果患者左侧颞下回(ITG.L) ALFF值升高，左侧枕下回(IOG.L)和额上回(SFG) ALFF值降低。R, P < 0.005)。对于FC分析，患者在SFG中显示FC降低。右额叶中回(MFG)R, P < 0.05)。SFG之间的FC。R和MFG。R与LH水平呈负相关(R=-0.594, P = 0.005)，与LH/FSH比值呈负相关(R=-0.521, P = 0.015)。结论多囊卵巢综合征可引起视觉空间工作记忆、面孔加工和情景记忆等脑区活动的改变。右额叶功能连通性降低与WPCOS患者高LH水平有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Psychoneuroendocrinology 医学-精神病学

CiteScore

7.40

自引率

8.10%

发文量

268

审稿时长

66 days

期刊介绍： Psychoneuroendocrinology publishes papers dealing with the interrelated disciplines of psychology, neurobiology, endocrinology, immunology, neurology, and psychiatry, with an emphasis on multidisciplinary studies aiming at integrating these disciplines in terms of either basic research or clinical implications. One of the main goals is to understand how a variety of psychobiological factors interact in the expression of the stress response as it relates to the development and/or maintenance of neuropsychiatric illnesses.