PCSK9 E670G polymorphism increases risk of coronary artery disease in a Chinese Han population.

IF 1.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

Journal of International Medical Research Pub Date : 2024-10-01 Epub Date: 2019-12-16 DOI:10.1177/0300060519892177

Zhang Lin, Shi Hong Wang, Da Yong Wei, Lu Min Wang, Zhong Wu Zhang

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引用次数: 0

Abstract

Objective: Coronary artery disease (CAD) is the leading cause of morbidity and mortality in the world. The proprotein convertase subtilisin/kexin type 9 (PCSK9) E670G polymorphism has been reported to be associated with variability in levels of low density lipoprotein cholesterol, a risk factor for CAD. However, the relationship between PCSK9 E670G and CAD is still not fully elucidated.

Methods: A total of 225 patients and 189 control subjects were recruited in this study. DNA was extracted from peripheral blood samples and was genotyped by mass array method. In addition, we also conducted a meta-analysis of case-control studies to elucidate the relationship of CAD and polymorphism.

Results: The GG genotype of PCSK9 E670G was associated with a higher risk of CAD [odds ratio (OR) 2.994, 95% confidence interval (CI): 1.174-7.631], even adjusting for risk factors (OR 2.794, 95% CI: 1.215-7.460). Logistic regression analysis showed that the dominant genetic model increased the CAD risk (OR 2.313, 95% CI: 1.070-6.983) after adjusting the confounding factors. Meta-analysis results of 13 studies revealed that PCSK9 E670G polymorphism was correlated with CAD risk under different genetic models.

Conclusion: Our results demonstrated that PCSK9 E670G genotype was associated with a high risk of CAD.

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PCSK9 E670G 多态性会增加中国汉族人群罹患冠心病的风险。

目的：冠状动脉疾病（CAD）是世界上发病率和死亡率最高的疾病。据报道，丙蛋白转化酶枯草酶/kexin 9 型（PCSK9）E670G 多态性与低密度脂蛋白胆固醇水平的变化有关，而低密度脂蛋白胆固醇是冠状动脉疾病的危险因素。然而，PCSK9 E670G 与 CAD 之间的关系仍未完全阐明：本研究共招募了 225 名患者和 189 名对照组受试者。方法：本研究共招募了 225 名患者和 189 名对照受试者，从外周血样本中提取 DNA，并采用大规模阵列法进行基因分型。此外，我们还对病例对照研究进行了荟萃分析，以阐明 CAD 与多态性的关系：结果：PCSK9 E670G的GG基因型与较高的CAD风险相关[几率比（OR）2.994，95%置信区间（CI）：1.174-7.631]，即使调整了风险因素（OR 2.794，95% CI：1.215-7.460）。逻辑回归分析表明，在调整了混杂因素后，显性遗传模型会增加 CAD 风险（OR 2.313，95% CI：1.070-6.983）。13项研究的元分析结果显示，在不同的遗传模式下，PCSK9 E670G多态性与CAD风险相关：我们的研究结果表明，PCSK9 E670G基因型与高CAD风险相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of International Medical Research 医学-药学

CiteScore

3.20

自引率

0.00%

发文量

555

审稿时长

1 months

期刊介绍： _Journal of International Medical Research_ is a leading international journal for rapid publication of original medical, pre-clinical and clinical research, reviews, preliminary and pilot studies on a page charge basis. As a service to authors, every article accepted by peer review will be given a full technical edit to make papers as accessible and readable to the international medical community as rapidly as possible. Once the technical edit queries have been answered to the satisfaction of the journal, the paper will be published and made available freely to everyone under a creative commons licence. Symposium proceedings, summaries of presentations or collections of medical, pre-clinical or clinical data on a specific topic are welcome for publication as supplements. Print ISSN: 0300-0605