Objective digital phenotypes of worry severity, pain severity and pain chronicity in persons living with HIV.

Abstract

Persons living with HIV report experiencing disproportionally severe and chronic pain and worry. However, no objective biomarkers of these subjective experiences have been developed. To address the lack of objective measures and assist in treatment planning, this study examined whether digital biomarkers of pain severity, pain chronicity and worry could be developed, using passive wearable sensors that continuously monitor movement. Results suggest that digital biomarkers can predict pain severity (r[35] = 0.690), pain chronicity (74.63% accuracy) and worry severity (r[65] = 0.642) with high precision, suggesting that objective digital biomarkers alone accurately capture internal symptom experiences in persons living with HIV.

Declaration of interest: N.C.J. is the owner of a free application published on the Google Play Store entitled 'Mood Triggers'. He does not receive any direct or indirect revenue from his ownership of the application (i.e. the application is free, there are no advertisements and the data is only being used for research purposes). C.O. has no conflicts to declare.