The Massachusetts Hepatitis C Testing Cascade, 2014-2016.

Microbiology insights Pub Date : 2019-06-21 eCollection Date: 2019-01-01 DOI:10.1177/1178636119857961
Quynh T Vo, Shauna Onofrey, Daniel Church, Kevin Cranston, Alfred DeMaria, R Monina Klevens
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引用次数: 2

Abstract

Objectives: To characterize hepatitis C testing in Massachusetts and guide stakeholders in addressing the needs of people living with hepatitis C.

Methods: All persons with a positive laboratory report for anti-hepatitis C virus (HCV) antibody, between 2014 and 2016, were included in the testing cascade. Outcomes were HCV tests received after a positive anti-HCV antibody test: nucleic acid test or genotype test. Logistic regression analyses were performed to determine factors associated with progression through the HCV testing cascade.

Results: Among those reported anti-HCV antibody positive, a total of 13 194 (61%) cases had a subsequent RNA-based test, and 79% (10 374/13 194) were confirmed with current, active HCV infection. For confirmed HCV cases, 44% (4557/10 374) had a genotype identified. The median time from an antibody-positive test to a RNA-based test was 29 days (interquartile range [IQR] = 7-151). Differences in moving through the testing cascade were observed by birth cohort and race/ethnicity.

Conclusions: Improved surveillance capture of demographic information is needed to help public health agencies ensure equity in HCV diagnosis and linkage to care.

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马萨诸塞州丙型肝炎检测级联,2014-2016。
目的:了解马萨诸塞州丙型肝炎检测的特点,并指导利益相关者解决丙型肝炎患者的需求。方法:在2014年至2016年期间,所有抗丙型肝炎病毒(HCV)抗体实验室报告阳性的人都被纳入检测级联。结果是抗HCV抗体检测阳性后接受HCV检测:核酸检测或基因型检测。通过HCV检测级联进行逻辑回归分析以确定与进展相关的因素。结果:在报告的抗HCV抗体阳性患者中,共有13194例(61%)进行了随后的基于rna的检测,其中79%(10374 / 13194)被确认为当前的活动性HCV感染。在确诊的HCV病例中,44%(4557/ 10374)有确定的基因型。从抗体阳性检测到rna检测的中位时间为29天(四分位数间距[IQR] = 7-151)。不同的出生队列和种族/民族观察到在测试级联中移动的差异。结论:需要改进人口统计信息的监测,以帮助公共卫生机构确保丙型肝炎病毒诊断的公平性和与护理的联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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